Fungi 4

Question 1

how can we best describe fungi?

Answer 1

can be unicellular or multicellular, intra/extracellular so immune response varies

endemic, opportunistic, propagate via neutrophil deficiency and HIV

Question 2

how does our innate and adaptive immune system respond to fungi invasion?

Answer 2

depends if they intracellular or extracellular

innate immune mediators being macrophages and neutrophils

Question 3

what are the TLRs and lectin like receptors located on macrophages and DCs that recognize the B glucans on the surface of the fungi?

Answer 3

dectins

Question 4

how does our adaptive immunity work against fungi?

name this facultative intracellular parasite living in macrophages

Answer 4

same mechanisms depending if fungi are extracellular or intracellular

histoplasma capsulatum
(IL12- IFN gamma)