8/06/22 Flashcards

(79 cards)

1
Q

how is pabrinex adminstered?

A

always IV

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2
Q

triad of dementia, gait disturbances and urinary incontinence?

why is this not alzheimers

Ix?

management?

A

normal pressure hydrocephalus
alzheimers presents with urinary incontinence later on

first kumbar puncture
ct/mri
ventriculoperitoneal shunting

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3
Q

what is the dose of lorazepam given in status epilepticus

diazepam?

A

8mg

10mg

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4
Q

what are the mainstay in treatment of stable angina?

A

Aspirin
Statin
Sublingual GTN
Beta blocker or rate limiting calcium channel blocker

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5
Q

in a patient with normal cholesterol levels after first stroke is a statin indicated?

A

yes shown to improve mortality

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6
Q

what is the criteria for asses pt for home oxygen requirements? COPD mx

A
FEV1<30%
cyanosis
polycythaemia
peripheral oedema 
jvp raised
o2 sats less than 92%
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7
Q

criteria for LTOT in COPD

what is timeframe for assessment?

A

abg 2 in 3 weeks

  • pO2 <7.3

if pO2 is 7.3-8 then offer of they have one of the following
polycythaemia
oedema
pulmonary htn

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8
Q

routine maintenance first 24 hours

A

25-30 ml/kg/day sodium chloride 0.18% in 4% glucose with 27 mmol/l potassium on day 1

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9
Q

when should hartmanns not be given?

A

in hyperkalaemia as it has K+

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10
Q

what is the risk of using large volumes of 0.9% saline ?

A

hyperchloraemic metabolic acidosis

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11
Q

what is in 0.9% saline?

A

154mm/l Na+

154mmol/l K+

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12
Q

HHS management goals?

A

normalise osmolality with 0.9 saline
replace fluid and elctrolytes 0.45 na+, cl-

normalise glucose

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13
Q

DKA management principles

A

fluid replacement
insulin
correction of electrolyte disturbance
long acting insulin continued and short stopped

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14
Q

what fluid in DKA?

A

isotonic saline

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15
Q

insulin administration in dka?

when should you infuse dextrose?

A

0.1unit/kg/hour

when glucose is <15mmol/l

5% dextrose

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16
Q

correction of electrolyte disturbancein DKA

A

serum potassium is often high on admission despite total body potassium being low
this often falls quickly following treatment with insulin resulting in hypokalaemia
potassium may therefore need to be added to the replacement fluids
if the rate of potassium infusion is greater than 20 mmol/hour then cardiac monitoring may be required

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17
Q

in acute management of dka what type of insulin

A

fixed rate whilst continuing regular injected long acting but stopping short acting

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18
Q

how is DKA resolution criteried

A

pH >7.3 and
blood ketones < 0.6 mmol/L and
bicarbonate > 15.0mmol/L

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19
Q

hypoglycaemia management
if awake?
if unable to swallow

A

10-20g oral glucose - short acting
like glucogel / dextrogel

IM glucagon
or IV glucose solution through large vein

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20
Q

how is specificity detected?

A

detection of true negative

= number of true negatives/ [true negatives and false positives] x100

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21
Q

what kind of ascites does nephrotic syndrome present?

A

low SAAG as albumin is lost through urine

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22
Q

low saag causes?

A

periotenal cancers - ovarian
chronic infection; tb
nephrotic syndrome

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23
Q

what parameters can diagnose DM

what common glucose is not a diagnostic measure?

A

fasting glucose >7
random glucose >11.1

urine dip
OGTT- when investigating impaired glucose tolerance
HBA1c

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24
Q

is HBA1C a good diagnostic measure fpr DM?

A

no

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25
differentiating a malignant melanoma from a benign pigmented lesion
An irregular pigment network may be highly important in differentiating a malignant melanoma from a benign pigmented lesion
26
Intramuscular glucagon may not work in?
alcohol-related hypoglycaemia, liver disease prolonged hypoglycaemia.
27
which antibiotics do not interact with warfarin?
gentamicin | broad spectrum - amoxicillin?
28
how is alzheimers managed? | how does the drug work?
cholinesterase inhibitors - pyridistigimine | increases functional acetylcholine at synapses
29
travellers diarrhoea?
e.coli
30
how does HTN happen in conns?
aldosterone secretions lead to increased plasma sodium whihc leads to fluid retention = htn
31
features of constrictive pericarditis
occurs post Mi / dresslers raised JVP kussmaul sign - paradoxical rise in JVP with inspiration pulsus paradoxus - cardiac output drop in inspiration heart sounds quiet due to pericardial effusion s3
32
what is kussmaul sign?
paradoxical rise in JVP on inspiartion
33
mx of rheumatic fever?
IV benzylpenicillin and
34
where is BNP secreted?
cardiac ventricles
35
what are the parameters for severe aortic stenosis
Peak gradient > 40 mmHg (note, in severe left ventricular dysfunction, a low peak gradient can be falsely reassuring) Valve area < 1.0 cm^2 Aortic jet velocity >4 m/s
36
asbestosis features on xray?
pleural plaques | pleural thickening
37
respiratory causes of clubbing malignancy infection inflammation
lung cancer - NSCLC empyema lung abscess cystic fibrosis bronchiectasis pulmonary fibrosis
38
dorsiflexion of big toe?
l5
39
foot eversion
s1
40
foot inversion?
l4
41
hip flexion
L2
42
knee extension?
L3
43
foot drop weakness or paralysis of dorsiflexion and eversion if inversion is intact
peroneal nerve lesion
44
foot drop weakness or paralysis of dorsiflexion and eversion if inversion is lost where is the lesion what is the most common cause?
l5 lesion | lumbosacral disc herniation
45
which anti hypertensive drugs are a common cause of ototoxiticty what other common drugs?
loop diueretics - furosemide gentamicin vancomycin - aminoglycoside
46
merlagia paresthetica
compression if lateral cutaneous nerve of the thigh underneath the inguinal ligament weight loss adviced
47
weakness of hip flexion, knee extension and absent knee jerk reflex?
femoral nerve damage
48
loss of plantar flexion toe flexio and weakness of foot inversion?
tibial nerve damage
49
why might a parkinsons patient experience dykinesia?
because levodopa at peak dose causes dystonia chorea or involuntary writhing
50
what side effects are caused by parkinson medication?
sleepiness hallucinations impulse control disorders
51
for chemotherapy-induced nausea
ondansetron
52
nausea and vomiting associated with for gastrointestinal causes
metoclopramide
53
nausea caused by or for intracranial causes (raised ICP, direct effect of tumour)
Haloperidol
54
adverse effect of triptans?
tingling tightness of throat/chest
55
what is the cause of an acute peripheral neuropathy?
GBS
56
hoffman reflex-
UMN sign | thumb contracts when distal phalanx tapped
57
causes of upgoing planters and absent ankle reflex
cord compression b12 MND friedrichs ataxia
58
what is internuclear opthalmoplegia what is a common cause of this?
R CN VI L CN III these communicate via MLF - conjugate gaze - horizontal = diplopia MS
59
crossed sign on neuro exam suggest where is the lesion? left brainstem lesion
brainstem left face / right arm/leg
60
what type of gait in parkinson
narrow based
61
what is a painless unilateral visual loss called what is it caused by? what would you see on opthalmoscopy
amaurosis fugax painless unilateral visual loss by a retinal artery emboli cherry red macula
62
acute angle glaucoma
painful blurred vision seeing haloes
63
prognosis of MS
<25 on diagnosis optic neuritis or sensory as a first presentation > cerebeller features long interval >1year few lesion on MRI
64
in chronic kidney disease what should be treated straight away? what are complications from this whats the med called?
high phosphate low calcium high pth hyperphosphataemia should be treated with phosphate binders - sevelamer vascular calcification
65
Mx of chronic kidney disease
sevelemr - phosphate binder then vit D caclimimetics - cincalcet
66
how does ureteral stricture present?
painful | mass on flank- assymterical dilatation of one kidney
67
renal cancer characteristically presents with?
palpable flank mass with pain
68
if you hear bruits - 1st line investigation?
arteriography
69
what is detected on a urine dipstick of uti?
nitrites | leukocytes
70
what imaging modality for chronic kidney disease?
Ultrasound then CT scan MRI to see a cancer
71
imaging for ADPKD
USS
72
first line ix for renal failure?
u&e
73
how is hypercalcaemia investigated
measure serum calcium first
74
what medication is safe to use in pregnancy for uti
nitrofurantoin | cephalexin
75
leukaemia IX how do you know it is axcute?
>20% blasts cells | bone marrow aspirate under microscopy
76
what ix allows to differ between aml and all
flow cytometry
77
in iron deficiency anaemia | what increases?
transferrin
78
what stain differentiates between myeloblasta and lymphoblasts?
sudan black
79
what drugs can preciciptate haemolytic anaemia in G6PD?
dapsone | antimalarial