neuro Flashcards

(65 cards)

1
Q

ipsilateral hemiplegia
same said loss of proprioception and vibration

contralateral loss of pain and temp

A

brown sequard

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2
Q

causes of brown sequard

A
cord trauma 
neoplams
disc herniation 
demyelination
epidual haemtoma
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3
Q

how does ipsilateral UMN weakness present in an exam of limbs?

tone
power
reflex

A

increased tone
hyperreflexia
leg lift

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4
Q

what are causes of bulbar palsy?

categorise them

A

absent jaw jerk
absent gag reflex
fasciculating tongue

infection: GBS,
inflammation: MG, MND
malignancy : neoplasm of brainstem
ischaemic: brainstem stroke

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5
Q

cerebeller syndrome signs?

A

DANISH

dysdiadochokinesia 
ataxia 
nystagmus 
intention tremor 
slurred speech
hypotonia
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6
Q

what causes cerebeller syndrome?

vitamin C

A

vascular: stroke; posteriro circulation
infection: lyme disease
inflammation: Multiple sclerosis
trauma
metabolic: alcohol
iotrogenic: carbamazepine
neoplastic: tumour , acoustic neuroma
hereditary: friedrichs

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7
Q

cerebeller syndrome causes simple

A

infection: Lyme
Inflammation: MS
Malignancy: acoustic neuroma, 2O mets from breast cancer, lung

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8
Q
cag trinucleotide affected - repeats 
choero 
dementia 
dystonia
saccadic eye movements

striatal colume loss and increased size of frontal horns of lateral ventricles

what is this?
Mx?

A

huntingtons

chorea - tetrabenzine

SSRI-
psychosis : olanzapine

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9
Q

diplopia causes

categorises

A

infection: sixth nerve palsy
inflammation: Graves, MG
malignancy: neoplasm of cranial nerves

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10
Q

which drug commonly causes dystonia?

A

metocllopramide

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11
Q

mx of encephalitis

what does it present with?

A

IV acyclovir and broad spectrum abx IV ceftriaxone 2g BD IV

seizures alongside characteristic infection signs ; neck stiffness, fever
altered mental state

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12
Q

management of epilepsy

A

lamotrigine - not teratogenic
levetiracetam
valproate- teratogenic

carbamazepine and gabapentin: focal , may worsen myoclonic seizures

ethosuximide good for absence

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13
Q

gabapentin
what is it used for?
SE?

A

focal seizures

anxiety, confusion, constipation

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14
Q

lamotrigine SE

what is it used for?

A
focal seizures 
blurred vision: diplopia 
arthralgia 
ataxia 
dizziness
headache 
rash 
tremor
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15
Q

valproate

SE

A
anaemia 
confusion
convulsions 
deafness
extrapyramidal disorders
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16
Q

phenytoin

se

A
acne
anorexia
constipation
dizziness
gingival hypertrophy
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17
Q

levetiracetam

A

headaches
feeling sleepy
blocked nose
itchy throat

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18
Q

what is the most common source of bleeding in a head trauma pt

pt had lucid period followed by deterioting consciousness and a headache

what would you see on a CT?

how do you differentiate between subdural

what constitues an emergency?
management?

A

this is an extradural bleed

middle meningeal artery

bi convex shape - blood is fresh so appears white as it is least dense
blood is clotted and old so appears darker, also banana shaped

midline shift on ct

burr hole

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19
Q

how can you medically manage subdural bleeds?

A

transexamic acid

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20
Q

foot drop
causes?
what level lesion?

A

L5 root lesion: radiculopathy - disc herniation

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21
Q

GBS

treatment

what infection most commonbly associated?

what are you worried about?

A

monitor ventilation- abg, serial spirometry
VTE- LMWH

medically: IV immunoglobulin, plasmapheresis

campylobacter, mycoplasma and EBV: so GI upset in a question could indicate

respiratory arrest- forced vital capacity

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22
Q

criteria for CT headl

A

More than 30 minutes retrograde amnesia.

Focal neurological deficit or seizure.

GCS <13 at any time (or <15 2 hours after injury).

More than 1 episodes of vomiting.

Loss of consciousness and any amnesia in patients who:

Are >65 years

Suffered a dangerous mechanism of injury (great height, road traffic accident)

Have evidence of coagulopathy (including anticoagulation with warfarin).

clinical evidence of skull fracture

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23
Q

horners syndrome

causes?

A

pancoast tumour
stroke
carotid artery dissection - NECK pain

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24
Q

stroke management

4.5 hours of presenting

A

alteplase - inr normal , acceptable bp

mechanical thrombectomy

aspirin 300mg 2 weeks

carotid ultrasound, CT/MR angiography

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25
inferior homonymous quadrantanopia means? where is lesion?
loss of vision in the same lower quadrant of visual field in both eyes parietal lobe
26
homonymous hemianopia with macula sparing
occipital lobe causes stroke brain abscess trauma
27
anosmia is a lesion where?
frontal lobe
28
superior homonymous quadrantanopia?
lesion is in temporal lobe | in a quarter of the same visual field- so above L/R
29
what is a hemianopsia? | if it is homonymous
loss of half the visual fiedl 1 nasal, 1 temporal
30
MS- affects which nerve?
optic nerve - optic neuritis : unilateral eye pain and visual problems RAPD- marcus gunn
31
anopia where is lesion?
total visual loss due to optic nerve
32
ipsilateral nasal hemianopia | lesion is
lateral of optic chiasm
33
homonymous hemianopia is loss of what? | where is lesion
lesion to optic tract complete loss of L/R visual field right optic tract lesion causes complete loss of left visual fiedl
34
pie in the sky
meyer loop
35
dorsal optic radiation
parietal lobe lesion | contralateral lower quadranopia
36
central necrosis and rim that enhances with contrast | mx
glioblastoma- vasogenic oedema | dexamethasone
37
what are symptoms of meningioma
arachnoid cap cells | will show contrast enhancement) and MRI, and treatment will involve either observation, radiotherapy or sur
38
acoustic neuroma | associated with what?
facial nerve palsy tinnitus hearing loss neurofibromatosi t2
39
Von hippel lindau
cerebller hemangiomas retinal : vitreous haemorrhages renal cysts phaeo
40
what optic sign does wernickes present with/
nystagmus
41
restleg leg syndrome | mx
dopamine agonist pramipexole benzo gabapentin
42
widening pulse pressure bradycardia irregular breathing is what? diagnosis? mx?
cushing triad for raised ICP head elevation 30 IV mannitol : osmotic diuretic controlled hyperventilation
43
what are two things pathogenomic of epileptic seizures?
tongue biting | raised serum prolactin
44
(bromocriptine, cabergoline) what problem do these drugs present in Parkinson patients
ergot derived dopamine receptor agonist impulse control
45
levopopa | side effects?
dopamine precursor given with decarboxylase inhibitor ``` palpitation anorexia dry mouth postural hypotension psychosis ``` dyskinesia at peak dose acute dystonia if stopped abruptly
46
MAO-B (Monoamine Oxidase-B) inhibitors
e.g. selegiline | inhibits the breakdown of dopamine secreted by the dopaminergic neurone
47
Antimuscarinics
block cholinergic receptors now used more to treat drug-induced parkinsonism rather than idiopathic Parkinson's disease help tremor and rigidity e.g. procyclidine, benzotropine, trihexyphenidyl (benzhexol)
48
refeeding syndrome | abnormality?
Hypophosphataemia Hypokalaemia Hypomagnesaemia Abnormal fluid balance
49
NMS Ix findings?
Creatine kinase leukocytosis pyrexia muscle rigidity htn, tachycardia, tachypnoea delirium
50
NF1
cafe au lait iris lisch nodules phaeo
51
whihc drugs worsen MG
``` penicillamine quinidine, procainamide beta-blockers lithium phenytoin antibiotics: gentamicin, macrolides, quinolones, tetracyclines ```
52
what is MG associated with? crisis mx?
perncious anaemia thymoma RA SLE plasmapheresis IV IG
53
erectile dynfunction parkinsonism dysdiakinesia ataxia ?
multiple system atrophy
54
MRI findings of MS?
periventricular plaques | Dawson fingers: often seen on FLAIR images - hyperintense lesions penpendicular to the corpus callosum
55
CSF MS
oligoclonal bands | intrathecal IgG
56
mx of MND prevents stimulation of glutamate receptors what subtype?
ALS | riluzole
57
complications of meningitis
sensorineural hearing loss | seizures
58
CSF viral meningitis white cells? glucose?
normal protein. very raised really high >50%
59
lamotrigine is started and patient has a skin flair up | what could this be?
stevens johnson syndrome
60
what malignancy is lambert eaton associated with?
small cell lung cancer | ovarian
61
Mx of Lambert eaton syndrome
prednisalone and aza | IV Immunoglobulin and plasma exchange
62
idiopathic ICp htn? drug causes? COMAAR surgical intervention?
``` ciclosporin oral combined pill mineralcorticoids/ steroids amiodarone abx: tetracyclines, sulhponimides ``` vit a lithium optic nerve sheath decompression and feenstration
63
HSV affects which lobe? they present with aphasia? Mx
temporal lobes petechian haemorhages aciclovir
64
what does the 4th nerve do? | what does a 4th nerve palsy look like
depresses eye moves it inwards- adduction | affected eye is deviated upwards and roatated outwards
65
LMN facial nerve plasy
``` Bell's palsy Ramsay-Hunt syndrome (due to herpes zoster) acoustic neuroma parotid tumours HIV multiple sclerosis* diabetes mellitus ```