8. Adverse Reactions of Transfusions Flashcards Preview

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Flashcards in 8. Adverse Reactions of Transfusions Deck (25):
1

Unusual symptom of TA-GVHD not seen in other tx rxns

Diarrhea

2

Non-immune mediated tx rx may involve what 3 things?

- Transfused component
- Pt's underlying condition
- Method of infusion

3

Tx rxn that is 5x more frequent in women than men

Post transfusion purpura

4

Leading cause of transfusion associated fatalities?

TRALI

5

When do DELAYED transfusion rxns occur?

Days or weeks (4-14 days)

6

Volume overload secondary to rapid, high volume; severe hypoxia, increased BP, CVP, pulmonary edema, cardiac failure

TACO

7

Recipient leukocyte antibodies, transfused cytokines; fever, chills, rigors

Febrile nonhemolytic

8

Usual cause of AHTR?

ABO incompatibility

9

Iron overload, multi-organ failure => kidney, liver, heart

Transfusion hemosiderosis

10

Timeframe to be classified as an ACUTE transfusion rxn?

< 24 hrs

11

2 hallmarks of intravascular hemolysis that may occur during AHTR?

Hemoglobinemia
Hemoglobinuria

12

ABO incompability; fever, chills, pain, hypotension

Acute hemolytic

13

Anti-IgA in IgA-deficient recipient; respiratory distress, hypotension

Anaphylactic

14

Donor HLA or granulocyte antibodies; hypoxemia

TRALI

15

Plasma allergen; rash, hives, flushing

Allergic, mild

16

Treatment for transfusion hemosiderosis

Deferoxamine, deferiprone, defersirox

Red cell exchange

17

Anti-HPA-1a or other plt antibody; thrombocytopenia

PTP Post transfusion purpura

18

Primary or secondary alloimmunization; unexplained drop in hgb

Delayed hemolytic

19

Donor septicemia or contamination during phlebotomy or handling; fever, chills => gram stain, culture unit

Sepsis

20

5 antigens commonly implicated in DHTR

E, Jka, c, Fya, K

21

Symptoms are similar to AHTR = must rule out hemolysis

Febrile, nonhemolytic transfusion rxn

22

Treatment for citrate toxicity transfusion reaction

CaCl

23

Viable donor lymphocytes attack recipient; fever, rash, diarrhea

TA-GVHD

24

Immune mediated tx rx may involve what 3 things?

- Antigen-antibody complexes

- Cytokine release

- Complement activation

25

Mechanical or chemical trauma to unit; fever, chills, pain, hypotension

Hemolytic