Immuno 6: Allergy

Question 1

Name 1 cytokine released from damaged epithelium secondary to exposure to an allergen/worm ?

Answer 1

TSLP

Question 2

Which T cells are involved with allergy response ?

Answer 2

Th2 cells

Question 3

List 3 important cytokines released by Th2 cells in an allergic response ?

Answer 3

IL-4
IL-5
IL-13

Question 4

Which cytokine released by Th2 cells is considered the master switch that causes Isotype switching of B cellls to IgE ?

Answer 4

IL-4

Question 5

How do allergens/worms cause Histamine and leukotriene release ?

Answer 5

They cause cross linking of IgE receptor on mast cells, which causes release of Histamine and leukotriene

Question 6

Oral exposure to allergens promotes…….

Answer 6

Immune tolerance with IgG and IgA

Question 7

Skin and respiratory exposure to allergens promotes……..

Answer 7

IgE sensitisation

Question 8

Which allergies develop in infants ?

Answer 8

Allergic dermatitis

Food allergies - milk, egg, nuts

Question 9

Which allergies develop in children ?

Answer 9

Asthma

allergic Rhinitis

Question 10

Which allergies tend to develop in adults ?

Answer 10

Drug allergies
Oral allergy syndrome
Occupational allergies
Bee sting allergy

Question 11

Name a bio marker for anaphylaxis?

Answer 11

Mast cell tryptase

is useful in anaesthetics to rule out anaphylax when there is acute hypotension and rash

Question 12

What is the gold standard test for food and drug allergy ?

Answer 12

Challenge tests

Question 13

Give 3 different types of anaphylaxis other than IgE ?

Answer 13

IgG- e.g monoclonal antibodies
Complement- dialysis membranes
Pharmacological- aspirin and NSAIDS

Question 14

What is a cause of Throat swelling which mimics anaphylaxis ?

Answer 14

C1 inhibitor deficiency

Question 15

What is the most important treatment of Anaphylaxis ?

Answer 15

IM adrenaline

Question 16

What is a cause of delayed food induced anaphylaxis ?

Answer 16

Beef, pork,lamb
Tick bites

Gelatine in vaccines can do it as well