Lecture 5 Flashcards
Explain how the poxvirus structure and replication is different to other types/forms of viruses?
- linear DNA genome
- Vey large and complex
- Enveloped
- Replication occurs within the cytoplasm
- Mainly targets endothelial cells
True or false statement: Poxviruses are able to replicate in enucleated (cells without nucleuses)
They are able to replicate in cells without nucleuses, however they still need to utilise the host cells machinery (ie. using the ribosomes)
What is a potential application of the particularly long poxvirus genome?
Allows things to be easily inserted into the genetic code
What is the main symptom that is present as a result of poxviruses?
Bright red splotches/spots on the skin
How are papillomavirus infected proteins likely to be oncagenic?
- Species genotype determines anatomic predilection as well as the level of risk for inducing cancer
- Code for proteins involved in cellular alterations
- E6 (early protein 6)- decreases the concentration of host cells p53 reducing the likelihood that the cell will undergo apoptosis
- E7 frees a protein in infected cells that will allow for the cell to go through the G1/S phase completely unchecked
Describe the main features of a polyomavirus?
- Circular double stranded DNA
- Virion- Icosahedral
- Not enveloped
- Replication occurs within the nucleus
- Targets multiple different host sites
- Fragility- resistant to the environment
- Host range- occurs in birds and mammals- reasonably host specific
What are the main symptoms involved in Budgerigar fledgling disease?
- Avian polymovirus
- Typical presentation is a well fleshed juvenile just prior to fledgling age with acute onset lethargy, crop stasis and death within 24-48 hours
What are the main features of papillomaviruses?
- Circular double stranded DNA
- Icosahedral shape
- Not enveloped
- Replication is intranuclear
- Typically target epithelial cells (skin, mucosal surface)
- Fragility- resistant to the environment
- Host range- amniotes
