Lecture 9 Flashcards
What is the genome of picornaviruses?
positive sense single stranded DNA
Are picornaviruses typically fast or slow replicators?
- Picornavirus replication time is very short
Why do enteroviruses typically cause neurological disease?
Two distinct cell types GUT and CNS neurons, however both contain the same receptor thus making them a target for polio
What is the typical shape of picornaviruses?
Icosahedral shape
What is the typical replication site of enteroviruses?
Replication occurs completely within the cytoplasm
Target of replication is normally the endothelial cells (usually respiratory intestinal epithelium)
Swine Vesicular disease is often mistaken for foot and mouth disease without serological testing they are almost impossible to distinguish what are some differences between foot and mouth disease?
Swine vesicular disease is much more resistant than foot and mouth and it resists acid treatment. It is pH stable at 3.0
How is EMCV (genus cardiovirus) normally transmitted to pigs?
EMCV rodent virus has a very large host range. Pigs probably obtain it through infected rodent carcasses. This is why rodent control around piggeries is such an important issue
What type of animals does FMD typically infect?
cloven hoofed animals
How is FMD usually transmitted and where is the source of amplification?
Major amplification site is the throat of the animals
Why is foot and mouth disease normally very persistent?
Low fidelity- not as much checking occurs with RNA dependant RNA polymerase and hence much more mutation occurs
Rate the common species in order of those that are most effected by FMD disease:
Cattle most severe
Pigs middle
Sheep the least severe of all
What is the cause of epidemic tremor within chickens?
Avian encephalomyelitis virus
