Lecture 14

Question 1

Are caliciviruses generally considered to be stable within their environment?

Answer 1

Yes. Survive in their environment for a very long period to time

Question 2

Name three main calci/birnaviruses of clinical significance:

Answer 2

Rabbit Haemorrhagic disease virus (RHDV1), Feline Calicivirus, Birnaviridae

Question 3

What are the three viruses that are part of the F3 vaccination protocol within cats?

Answer 3

Calicivirus, Herpes, Parvo

Question 4

What are the general effects of Infectious bursal disease on the host?

Answer 4

Immunosuppression and increased susceptibility to other . viruses

Question 5

What is a prion?

Answer 5

Only protein, no DNA or RNA

Question 6

Why are prionoses called spongiform encephalopathies?

Answer 6

Cause tissues within the brain to have a sponge like appearance

Question 7

What is the prion hypothesis?

Answer 7

• We ingest the scrapie prion protein
• It sits next to our normal proteins and causes them to fold in an incorrect way
• Prion proteins then cause disease

Question 8

Describe the conversion in the structure of the protein when it is converted from PrPC to PrPSC:

Answer 8

Results in the conversion of an alpha helix to a beta-pleated sheet . In the process making it resistant to proteases.

Question 9

How is sCJD different to vCJD?

Answer 9

sCJD has a much older age onset and death is usually a lot quicker