Lecture 7

Question 1

What is the genome of herpesviruses?

Answer 1

double stranded linear DNA

Question 2

Are herpesviruses enveloped on non-enveloped?

Answer 2

Herpes viruses are enveloped

Question 3

Where does replication occur within herpesviruses?

Answer 3

replication is intranuclear

Question 4

Describe the lifecycle of herpes:

Answer 4

1. Gets into the cell
2. Uncoats and then travels to the nucleus
3. Replicative stages of mid-early and late
4. They get their lipid from inside the cell itself – the lifecycle is all the same except for this element of it (ie. Not taking the cell membrane with them)

Question 5

Describe the characteristics of Alphaherpesvirinae:

Answer 5

very fast in their reproduction leading to rapid destruction
of cell

Question 6

Describe the characteristics of Betaherpesvirinae

Answer 6

much slower productive cycle meaning a longer time to . destroy

Question 7

Describe the characteristics of Gammaherpesvirinae:

Answer 7

specific for the T cell and B cells

Question 8

What is the basic structure of herpes genomes?

Answer 8

• Terminal repeat at each end
• Two major coding regions US and UL
• coding regions have a series of internal repeats

Question 9

What are the two main means of transmission for Herpes Viruses?

Answer 9

• aerosol transmission

- direct transmission via mucous membranes

Question 10

Where does the parasite hide during the latency phase?

Answer 10

• lives within the ganglia of the sensory neurons

Question 11

How does the Herpes virus acquire its cell membrane?

Answer 11

It gets the cell membrane from within the cell itself

Question 12

Where is Cercopithecine herpesvirus B naturally found and what is the impact should it infect humans?

Answer 12

Normally found within monkeys. Generally when it infects humans it will result in fatality

Question 13

Where is human herpesvirus 1 found and what is its impact upon humans?

Answer 13

Very common within humans and it causes cold sores

Question 14

What is the appearance of human herpes virus 2 and where does it normally infect?

Answer 14

Typically seen as lesions on the genitals:

Question 15

Humans herpesvirus 3 is colloquially referred to as “chickenpox” if it were to come out of latency what condition would it cause?

Answer 15

shingles

Question 16

What is the species that gallid herpesvirus 1 (ILT) normally infects and what is usually the cause of death?

Answer 16

• Normally infects chickens and pheasants

- Death normally occurs by occlusion the trachea due to haemorrhage

Question 17

What types of cells does gallid herpesvirus 2 normally infect and what generally causes death?

Answer 17

Gallid herpesvirus 2 is generally associated with Marek’s disease. Occurs in chickens. Infects T-cells and B-cells and can be cancerous when it begins to invade other hosts

Question 18

What are the common clinical signs observed from equine herpes virus 1?

Answer 18

neuropathy and abortion

Question 19

What are the symptoms of suid herpesvirus one?

Answer 19

• high levels of abortion

- cattle often experience itching

Question 20

What are the symptoms of Malignant Catarrhal fever?

Answer 20

• Acelphaline herpesvirus 1 and ovine herpesvirus 2 both lead to MCF within
• generalised catarrhal inflammation and necrotic lesions of mucous membranes