Tissue Architecture Flashcards
What is the main molecule in intermediate filaments
Lamin
Function of intermediate filaments with nuclear lamina
Underlies and strengthens nuclear envelope
Where can you frequently find intermediate filaments
Anchored to plasma membrane at cell-cell junctions
What forms the mitotic spindle
Microtubules
y-tubulin function
Microtubules grow at their plus ends from the y-tubulin ring complexes of the centrosome
Taxol action
Binds and stabilizes microtubules
Colchicine, colcemid action
Binds tubulin dimers and prevents polymerization
Vinblastine, vincristine action
Binds tubulin dimers and prevents polymerization
Microfilaments/actin are essential for
Cell movements- locomotion, phagocytosis, cell division
Phalloidin function
Binds and stabilizes actin filaments
Cytochalasin function
Caps actin filament plus ends, preventing polymerization there
Latrunculin function
Binds actin monomers and prevents their polymerization
Explain the synthesis of collagen
Synthesized as preprocollagen in rough ER and converted to procollagen in ER lumen
Hydroxylation of proline and lysine, glycosylation of selected hydroxylysine residues in ER lumen
Self assembly of tropocollagen, initiated by disulfide bond formation in the carboxy terminal region, triple helix formation in ER lumen and Golgi
Procollagen packed into secretory vesicles
Procollagen secreted and converted to collagen in extracellular space
Condition due to mutation in collagen or collagen synthesis gene
Ehlers-Danlos syndrome
Adherens junction use what CAMs and cytoskeletal attachment and intracellular adaptors
Cadherins
Actin filaments
Catenins/vinculin
