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Path 2019 > Acute and Chronic Inflamation > Flashcards

Acute and Chronic Inflamation Flashcards

1
Q

cells in acute inflamation

A

neutrophils, monocytes, eosinophils

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2
Q

cells in chronic inflamation

A

monocytes, lymphocyes, plasma cells

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3
Q

cardinal signs

A

rubor, tumor, dolor, calor, functio laesa

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4
Q

acute inflammation major steps

A

recognition of injury, change in vascular flow/permeability, leukocyte extraversion

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5
Q

what is involved in injury recognition

A

TLR on dendritic cells> TNF/IL1 and histamine (mast cells) > vasodilation/increased permeability

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6
Q

injury recognition, slow vs fast

A

TNF/IL1 vs histamine

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7
Q

change in vascular flow

A

brief constriction, arteriolar vasodilation, erythema and warmth.

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8
Q

why increased permeability

A

increased RBC concentration increases viscosity, decreases flow

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9
Q

transudate

A

hydrodynamic, leaky fluid, low cell/protien

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10
Q

exudate

A

inflammation> leaky fluid, high cell/protien levels. specific gravity greater than 1.015

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11
Q

leukocyte extraversion steps

A

margination, rolling/selectin, integrin/adhesion/transmigration

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12
Q

margination

A

leukocytes accumulate along vascular endothelium

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13
Q

rolling/selectin

A

TNF/IL1 increase selectin

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14
Q

adhesion/integrins

A

TNF/ILI increases Vcam and Icam, increase high affinity in integral on leukocyte

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15
Q

transmigration

A

leucocytes have PECAM1, piece BM and enter extravascular tissue

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16
Q

chemotaxis

A

leukocytes move towards bacteria, chemokine, complement, where neutrophils phagocytosis

17
Q

resolution components (3)

A

mediators, systemic change, outcome

18
Q

mediators

A

vasoactive, initiate/regulate, lots

19
Q

systemic change

A

fever, leukocytosis, acute phase reactants, sepsis…

20
Q

fever

A

IL1, TNF (Macrophage)

21
Q

leukocytosis

A

Il1, TNFa (macrophages)

22
Q

acute phase reactants

A

Il6 (made by Mphage)

23
Q

outcomes for acute include

A

resolution, chronic, fibrosis

24
Q

chronic inflamation

A

lots of macrophages! can be granulomatous

25
Q

granulomatous inflammation

A

immune or non immune

26
Q

purulent

A

accumulation of pus (dead neutrophils)

27
Q

suppurate/suppurative

A

produce pus

28
Q

abscess

A

collection of neutrophils (walled off pus)

29
Q

fibrinous

A

protein rich

30
Q

serous

A

protein poor, few cells

31
Q

histamine and inflammation

A

mast cell, basophils, platelets, vasodilation and permeability

32
Q

decreased colloid osmotic pressure

A

transudate

33
Q

icam

A

intercellular adhesion molecule, ligand for inrwggrgin

34
Q

collegenase

A

pierces the basement

35
Q

pain mediators

A

prostaglandins, bradykinin, serotonin

36
Q

anti inflammatory signals

A

IL10, TGFb (produced by macrophages)

37
Q

IFNy

A

chronic inflammation - part of chronic

Path 2019 (7 decks)

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