Proteins - Lecture Fourteen

Question 1

Drugs that bind or inactivate common or multiple targets

Answer 1

Causes numerous side effects

Question 2

HIV protease enzyme is homo-dimeric

Answer 2

It contains two amino acid chains, both identical

Question 3

HIV protease

Answer 3

Is a homodimer formed of two identical amino acid chains

Question 4

HIV protease cleaves bonds between what amino acids

Answer 4

Phenylalanine and proline or tyrosine and proline

Question 5

What bond do you need to cut to cleave a protein?

Answer 5

Peptide bond

Question 6

Steps to make a drug

Answer 6

Build a peptide-like backbone Add some bulky side groups so it fits the active site
Design the rest of the drug so it can be absorbed from a tablet