9 NSAIDS Flashcards
(19 cards)
What does NSAIDS stand for?
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
What are the characteristics of NSAIDs?
Decrease inflammation
Relive mild to moderate pain
Decrease elevated body temperature
Decrease blood clotting
What is the best rep of NSAIDS
Aspirin
Are lipidlike compounds
Prostaglandins
Referred to as eicosanoids as they are derived from the same 20-carbon fatty acids that are double bonds
Prostaglandin
Thromboxanes
Leukotrienes
Primary enzyme system
Cyclooxygenase (COX)
Second system
Lipoxygenase
Where do prostaglandin and thromboxanes get synthesized?
What is the pathway for leukotrienes
Lipoygenase
A normal constituent in certain cells and prostaglandins synthesized by this enzyme are typically responsible for mediating, normal cell activity and maintaining homeostasis
COX-1
Injured cells synthesize this enzyme
COX-2
This medication is supported inhibitor of all cyclooxygenase activity, and thus have the potential to affect a number of conditions involving excessive prostaglandin and thromboxane production
Aspirin
Clinical applications of aspirin
Pain and inflammation
Fever
Vascular disorder
Cancer
Adverse effects of aspirin
GI problems
Hepatotoxicity
Nephrotic syndrome
This drugs inhibit the synthesis of the inflammatory prostaglandins while sparing the synthesis of beneficial prostaglandins
COX-2
It is known also as paracetamol and it is part of your COX-2 agents. It is not associated with upper gastrointestinal tract irritation.
Acetaminophen
Where do nsaid drugs get absorbed?
Stomach, small intestine
80 to 90 percent is bounded to?
Plasma
10 to percent is?
Distributed to the body
