Aspirin Flashcards
1
Q
Presentation
A
300 mg chewable tablets
300 mg soluble or water dispersible tablets
2
Q
Pharmacology
A
Analgesic, antipyretic, anti-inflammatory and antiplatelet aggregation agent
Actions:
- Minimise platelet aggregation and thrombus formation in order to retard progression of coronary artery thrombosis in ACS
- Inhibits synthesis of prostaglandins - anti-inflammatory actions
3
Q
Metabolism
A
- Converted to salicylate in the gut mucosa and liver
- excreted mainly by the kidneys
4
Q
Indications
A
ACS
5
Q
Contras
A
- Hypersensitivity to aspirin/salicylates
- Actively bleeding peptic ulcers
- Bleeding disorders
- Suspected dissecting aortic aneurysm
- Chest pain associated with psychostimulant OD if SBP >160 mmHg
6
Q
Precautions
A
- Peptic ulcer
- Asthma
- Anticoagulants
7
Q
Route of adminstration
A
Oral
8
Q
Side effects
A
- Heartburn, nausea, GI bleeding
- Increased bleeding time
- Hypersensitivity reactions
9
Q
Special notes
A
- Aspirin in contraindicated for use in acute febrile illness in children and adolescents
- Anti-platelet effects of aspirin persist for the natural life of platelets
10
Q
Oral effects
A
Onset: n/a
Peak: n/a
Duration: 8-10 days
11
Q
ACS
A
300 mg oral if not already administered
Single dose only
