Misoprostol Flashcards
1
Q
Presentation
A
200 mcg tablet
2
Q
Pharmacology
A
Synthetic prostaglandin
Actions:
- Enhance uterine contractions
3
Q
Metabolism
A
- Converted to active metabolite misoprostol acid in the blood
- metabolised in the tissues and excreted by the kidneys
4
Q
Indications
A
PPH (Primary postpartum haemorrhage)
5
Q
Contras
A
- Allergy to prostaglandins
- Exclude multiple pregnancy before drug administration
6
Q
Precautions
A
History of asthma
7
Q
Route of administration
A
Oral
8
Q
Side effects
A
- Hyperpyrexia
- Shivering
- Abdominal pain
- Diarrhoea
9
Q
Special notes
A
Side effects are more likely with > 600 mcg oral dose
10
Q
Oral effects
A
Onset: 8-10 mins
Peak: n/a
Duration: 2-3 hrs
11
Q
PPH
A
Fundus remains not firm (in spite of previous Mx)
- 800 mcg oral
