primary biliary cholangitis Flashcards
1
Q
what is it
A
chronic disorder with progressive destruction of small bile ducts
2
Q
what does it lead to
A
cirrhosis
3
Q
more common in men or women
A
women
4
Q
what are found in most patients
specific to PBC
A
serum anti-mitochondrial antigen M2
5
Q
symptoms (5)
A
- pruritus
- fatigue
- jaundice
- hepatomegaly.
- xanthelasma
6
Q
associated disorders
A
- autoimmune
- keratoconjunctivitis Wicca (dry eyes and mouth)
- renal tubular acidosis
- coeliac disease
- interstitial pneumonitis
7
Q
investigations
A
- mitochondrial antibodies (ELISA)
- ultrasound
- biopsy
8
Q
are hepatic granulomas present
A
yes
9
Q
treatment (3)
A
- ursodeoxycholic acid
- steroids
- liver transplant
10
Q
how is pruritus controlled.
A
- colestyramine
- rifampicin !
11
Q
complications (3)
A
- cirrhosis
- osteoporosis
- osteomalacia
12
Q
what should patients with jaundice be ordered
A
liver transplant
