wilsons Flashcards
1
Q
where is dietary copper absorbed
A
stomach and upper small intestine
2
Q
how is copper transported
A
bound to albumin
3
Q
how is copper normally excreted
A
in bile and faeces
4
Q
what is Wilson’s disease
A
copper deposition in various organs
5
Q
what type of inheritance is it.
A
autosomal recessive
6
Q
what chromosome is it on
A
13
7
Q
what are basal ganglia like.
A
damaged and show cavitation
8
Q
symptoms
A
- tremor
- dysarthria
- dementia
- kayser-fleischer ring
9
Q
investigations
A
- serum copper (reduced)
- liver biopsy
- anaemia
- genetic analysis
10
Q
treatment
A
penicillamine
11
Q
penicillamine side effects
A
- skin rashes
- leucopenia
- skin changes
- renal damage
12
Q
if cirrhosis occurs what treatment is given
A
liver transplant
