Myelodysplastic syndromes Flashcards
1
Q
pathology of aplastic anemia
A
immunological attack against hematopoietic stem cells
2
Q
pathology of paroxysmal hemoglobinuria
A
mutation in PK gene allowing them to escape the immune system but still be killed by the complement system
3
Q
age related clonal hematopoiesis ARCH
A
increases risk of CV disease bc TET2 mutated cell induce inflammation which is a risk factor for atherosclerosis
4
Q
most important MDS is
A
5q- syndrome. This has hyperactivation of p53. Treat with lenalidomide
