JVD 2015 #4 - Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs

Question 1

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

which types of SCC have higher metastatic rates?

what have primary treatment options been historically?

what is typically the cause of death in cats?

Answer 1

tonsillar and lingual;

surgery and radiotherapy;

euthanasia secondary to local disease (poor quality of life)

Question 2

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

what is accelerated radiotherapy?

hyper fractionated?

Answer 2

accelerated involves total tx delivered over a shorter time period,

multiple small doses delivered at shorter intervals (in this study BID x 9d);

hyperfractionated = larger number of fractions

Question 3

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how was radiation delivered?

with what protocol?

what chemotherapy was used and why?

Answer 3

linear accelerator;

BID for 7/9 days in a run; 3.5Gy fractions for a total of 49Gy with a minimum of 6h btwn fractions;

carboplatin as a radio sensitizer

Question 4

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how many cats received a complete response (complete regression of all measurable dz)? partial response?

what were the side effects?

Answer 4

4/5 cats had complete remission; partial 1/5;

grade 2 oral mucositis, grade 2 and 3 cutaneous dermatitis

Question 5

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how many cats died secondary to tumor recurrence? due to mets?

Answer 5

1 (stage III);

1 with tonsillar SCC had pulmonary mets which developed after treatment

Question 6

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al, how many dogs achieved complete remission by 6-10weeks following completion of therapy?

Answer 6

all 3/3

Question 7

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how many dogs died secondary to metastatic disease what were the other outcomes?

Answer 7

1/3 due to distant mets; 1 to cardiac failure, and 1 still in complete remission