lecture 3

Question 1

angina

Answer 1

• produced when the heart is not getting enough oxygen

- caused by partial blockage of blood vessels that provide oxygen to the heart

Question 2

how can angina be treated

Answer 2

• lifestyle changes (smoking, weight, healthier diet)
• drug therapy
• surgery - to clear and replace the blocked coronary artery

Question 3

How to help angina symptoms

Answer 3

metoprolol will:

• reduce the frequency of angina
• not cure angina

Question 4

When should metoprolol be taken?

Answer 4

• must be taken everday prophylactically to treat chronic diseases such as heart disease
• some non prophylactically to prevent or relieve symptoms ie before or during attack

Question 5

how will metoprolol be adiminstered

Answer 5

• given as a tablet and swallowed

- dissolves in fluids of the stomach and small intestine

Question 6

what are other ways of adiminatrating a drug

Answer 6

• injection

- topically (lung inhalation)

Question 7

How does metoprolol reduce agina

Answer 7

• exercise releases adernaline into the blood stream which binds to the heart receptors making the heart cell to contract more quickly which takes energy which = aginal pain
• metoprolol blocks the binding of adrenaline reduces o2 debt and angina

Question 8

affinity

Answer 8

• is the tendency of the drug to bind to its target

- depends on the existence of chemical forces of attraction between the drugand its target

Question 9

efficacy

Answer 9

-activation

Question 10

adrenaline vs metoprolol

Answer 10

adrenaline:
- affinity and efficancy 
- binding and activation
agonsits binds to and activates receptor 
Metoprolol
- affinity no efficacy 
- binding no activation
- antangonsit binding blocks agonsit binding and recpetor activation

Question 11

what is the ideal dose of metoprolol

Answer 11

• a daily dose of 200-400mg metorolol is used effectivley treat angina