Abnormal Mood Flashcards Preview

Psychiatry > Abnormal Mood > Flashcards

Flashcards in Abnormal Mood Deck (10):
1

What are the Appetitive/Approach Systems

Ascending dopamine systems - mesolimbic/cortical projection

2

What are the Aversive/Defensive Systems?

Ascending serotonin systems
NA/CRF peptide transmitters

3

Is depression more common in women or men or equal?

Twice as common in women

4

What is depression associated with?

Disability and Quality of life
Disease

5

What increases the risk in first degree relatives?

MDD (3X) or BDP (2X) in the proband

6

What are endocrine changes associated with major depression regarding the adrenals?

Increased ACTH
Increased Cortisol
Elevated CORT in urine/saliva
Increased CRH in CSF
Blunted ACTH to CRH
Enlarged Adrenal Glands

7

What are endocrine changes associated with major depression regarding the thyroid?

Increased TRH and CSF
TSH response blunted in 20-25% despite normal basal TSH, T3 and T4

8

What is the Anterior Insular Cortex?

Dense connectivity with Anterior Cingulate Cortex
Long considered visceral sensory region
Co-activation of AIC and ACC during almost all studies of emotion

9

What does the Anterior Insular Cortex send?

Parallel descending projections to sensory and motor nuclei in brainstem

10

What is the Anterior Insular Cortex proposed as?

Limbic motor (ACC) and sensory (AIC) cortices that engender the feeling (awareness) and motivation (agency) associated with emotion