Flashcards in Abnormal Mood Deck (10):
What are the Appetitive/Approach Systems
Ascending dopamine systems - mesolimbic/cortical projection
What are the Aversive/Defensive Systems?
Ascending serotonin systems
NA/CRF peptide transmitters
Is depression more common in women or men or equal?
Twice as common in women
What is depression associated with?
Disability and Quality of life
What increases the risk in first degree relatives?
MDD (3X) or BDP (2X) in the proband
What are endocrine changes associated with major depression regarding the adrenals?
Elevated CORT in urine/saliva
Increased CRH in CSF
Blunted ACTH to CRH
Enlarged Adrenal Glands
What are endocrine changes associated with major depression regarding the thyroid?
Increased TRH and CSF
TSH response blunted in 20-25% despite normal basal TSH, T3 and T4
What is the Anterior Insular Cortex?
Dense connectivity with Anterior Cingulate Cortex
Long considered visceral sensory region
Co-activation of AIC and ACC during almost all studies of emotion
What does the Anterior Insular Cortex send?
Parallel descending projections to sensory and motor nuclei in brainstem