Pharmacology of Anxiolytic Drugs Flashcards Preview

Psychiatry > Pharmacology of Anxiolytic Drugs > Flashcards

Flashcards in Pharmacology of Anxiolytic Drugs Deck (20):
1

What drugs can treat Anxiety?

Barbiturates
Benzodiazepines
Antidepressants
Buspirone
Pregabalin
B-blockers

2

What are the effects of benzodiazepines?

Reduce anxiety and aggression
Hypnosis/sedation
Muscle relaxation
Anticonvulsant
Anterograde amnesia

3

What do benzodiazepines do?

Increase GABA-mediated inhibition

4

What is GABA?

Gamma amino butyric acid
Main inhibitory transmitter in the brain
Glycine restricted to spinal cord and brain stem

5

What does GABA do?

Causes hyperpolarisation of target cells

6

What are clinical uses for benzodiazepines?

Acute extreme anxiety
Hypnosis
Alcohol withdrawal
Mania, Delirium
Rapid tranquillisation
Premed before surgery
Status epilepticus

7

What are problems with benzodiazepines?

Fairly safe in overdose
Paradoxical aggression
Amnesia and impaired coordination
Cause tolerance and dependance

8

What is the neuroadaptation of the GABA response?

Chronic treatment causes reduced response to GABA
Withdrawal results in anxiety/convulsions possibly due to decreased density of BZ receptors

9

What should you switch to when trying to withdraw from benzodiazepines?

Diazepam/chlordiazepoxide

10

What can SSRI's be used for?

Panic disorder, OCD,
PTSD, phobias, GAD

11

What are tricyclics used for?

2nd line for Panic Disorder

12

What can venlafaxine be used for?

GAD

13

What can moclobemide be used for?

Social anxiety disorder

14

What do ethanol, neurosteroids and barbiturates exhibit?

Anxiolytic properties

15

What do inverse BDZ agonists have?

Anxiogenic properties

16

What do SSRI's do acutely?

Increase extracellular 5-HT and have anxiogenic properties

17

What do SSRI's do when given chronically?

Display anxiolytic properties

18

When would you consider giving pregablin for anxiety?

When patient unresponsive to other treatments

19

What are B-blockers best for treating?

Somatic symptoms such as palpitation/tremor

20

What is Buspirone?

5-HT1A receptor partial agonist, presynaptc dopamine antagonist at the D2, D3 and D4 receptors