Flashcards in Pharmacology of Anxiolytic Drugs Deck (20):
What drugs can treat Anxiety?
What are the effects of benzodiazepines?
Reduce anxiety and aggression
What do benzodiazepines do?
Increase GABA-mediated inhibition
What is GABA?
Gamma amino butyric acid
Main inhibitory transmitter in the brain
Glycine restricted to spinal cord and brain stem
What does GABA do?
Causes hyperpolarisation of target cells
What are clinical uses for benzodiazepines?
Acute extreme anxiety
Premed before surgery
What are problems with benzodiazepines?
Fairly safe in overdose
Amnesia and impaired coordination
Cause tolerance and dependance
What is the neuroadaptation of the GABA response?
Chronic treatment causes reduced response to GABA
Withdrawal results in anxiety/convulsions possibly due to decreased density of BZ receptors
What should you switch to when trying to withdraw from benzodiazepines?
What can SSRI's be used for?
Panic disorder, OCD,
PTSD, phobias, GAD
What are tricyclics used for?
2nd line for Panic Disorder
What can venlafaxine be used for?
What can moclobemide be used for?
Social anxiety disorder
What do ethanol, neurosteroids and barbiturates exhibit?
What do inverse BDZ agonists have?
What do SSRI's do acutely?
Increase extracellular 5-HT and have anxiogenic properties
What do SSRI's do when given chronically?
Display anxiolytic properties
When would you consider giving pregablin for anxiety?
When patient unresponsive to other treatments
What are B-blockers best for treating?
Somatic symptoms such as palpitation/tremor