ABO

Question 1

ABO antigens

Answer 1

carbs attached to red cell surface

Question 2

chromosome for ABO

Answer 2

9

Question 3

A antigen

Answer 3

N-acytlegalactose amine

Question 4

B antigen

Answer 4

galactose

Question 5

what does chrom 9 code for

Answer 5

transferase to place A or B antigen depending on gene

Question 6

what does chrom 19 code for

Answer 6

FUT1,2,3 that code for transferase to put fucose on carb chains (RBC, secretions)

Question 7

FUT 1

Answer 7

codes for type 2 substances

Question 8

type 2 substances

Answer 8

RBC

Question 9

FUT 2

Answer 9

codes for type 1 substances
- Se gene

Question 10

type 1 substances

Answer 10

secretions

Question 11

where is the secretion gene located

Answer 11

chrom 19

Question 12

what does secretion gene do

Answer 12

codes for transferase to act on type 1 substances to make an H substance

Question 13

H substance precursor chain (w/o fucoses)

Answer 13

(top)
gal
glc-nac
gal
glc

Question 14

where does FUT 3 act

Answer 14

fucosyl transferase adds fucose to subterminal location on H chain
- lewis gene (Le)

Question 15

lewis A

Answer 15

H substance without terminal fucose but with subterminal fucose = tot 1 fucose

Question 16

lewis b

Answer 16

H substance with terminal fucose and subterminal fucose = tot 2 fucose

Question 17

how are secretions turned into A or B antigens

Answer 17

same transferase as RBC

Question 18

describe bombay patients

Answer 18

no H substance = no A, B or lewis expression

Question 19

most to least detectible H substance on antigens

Answer 19

O>A2>B>A2B>A1>A1B

Question 20

A1 subgroup

Answer 20

A transferase on straight and branchy
- pos anti A and Anti-A1 lectin

Question 21

A2 subgroup

Answer 21

A transferase only onto linear H branches
- pos w/ anti A
- neg a/ anti -A1

Question 22

A3

Answer 22

mixed field agglutination

Question 23

A(end)

Answer 23

weak anti-A agglutination = weak mixed field

Question 24

Ax

Answer 24

weak agglutination with only AB

Question 25

Am

Answer 25

A in saliva, anti-A neg

Question 26

Ay

Answer 26

small amt antiA in saliva

Question 27

Ael

Answer 27

needs elution to detect - secretions only H substance

Question 28

B3

Answer 28

mixed field with anti B

Question 29

Bx

Answer 29

weakly reactive anti-B

Question 30

dolichos bifilarous

Answer 30

A1 specificity - flowers

Question 31

banderiea simplicifolia

Answer 31

B subgroup detection

Question 32

ulex eruopa

Answer 32

H substance detection (bombay/para)

Question 33

what determines secretor status

Answer 33

- FUT2 on chromosome 19 making the type 1 secretion substance

Question 34

risky transplants

Answer 34

due to carbohydrates on secretions

Question 35

Le(ab)

Answer 35

antibody reacts with both Le(a) and Le(b)

Question 36

Le(bH)

Answer 36

antibody reactis with only Lewis b that do not have A or B sugar attached

Question 37

Ig identitidy of lewis antigens

Answer 37

IgM

Question 38

the immunodominant sugar responsible for group B specificity is

Answer 38

d-galactose