blood groups

Question 1

Kidd system immunoglobulin type

Answer 1

IgG

Question 2

true or false
the kidd system antigens can bind compliment

Answer 2

true
- IgG but can bind

Question 3

enzyme effect on Kidd system

Answer 3

enhanced

Question 4

Kidd system antigens

Answer 4

antithetical: Jka, Jkb
Jk3 present with a or b
-> cells will have Jka/b and 3

Question 5

Kell system antigens

Answer 5

antithetical: K-k, Jsa-Jsb, Kpa-Kpb

Question 6

frequency of kell system antigens

Answer 6

k, Kpb, Jsb: 100
K: 9

Question 7

frequency of kidd system antignes

Answer 7

Jka: 75
Jkb: 75
JK3: 100

Question 8

duffy system antigens

Answer 8

antithetial: Fya-Fyb

Question 9

duffy system immunoglobulin type

Answer 9

IgG

Question 10

enzyme interaction with duffy system antigens

Answer 10

destroyed by enzymes

Question 11

special characteristics of duffy

Answer 11

duffy null prevents vivax entry
syntetic to Rh
- GATA 1 mutation = no duffy on red cells only (no antibodies made)

Question 12

lutheran system antigens

Answer 12

• Lub: IgG
• Lua: IgM

Question 13

chemical interaction with lutheran system

Answer 13

destroyed by DTT

Question 14

special characteristics of lutheran

Answer 14

mixed field reactions

Question 15

P system antigens

Answer 15

non antithetical: P1, P, Pk, p (null)

Question 16

immunoglobulin type of P system

Answer 16

IgM -> normally anti P1

Question 17

special characteristics of P

Answer 17

donath-landsteiner
gene codes for galactose transferase

Question 18

MNS system antigens

Answer 18

M-N, S-s, U

Question 19

MNS system nulls

Answer 19

Mk: whole system
Ena: MNS null but U pos
U: absence of glycophorin B

Question 20

MNS system immunoglobulin type

Answer 20

M-N: IgM
S-s: IgG

Question 21

enzyme reaction with MNS system

Answer 21

destroyed by enzymes

Question 22

special consideration for MNS

Answer 22

dosage, M/N may react into 37 phase (significant), falciparum entry point
-> anti-N made transiently by dialysis patients

Question 23

MNS system frequencys

Answer 23

M: 85
N: 70
S: 50
s: 90
U: 100

Question 24

P system frequencies

Answer 24

P1: 80
P2: 100
p: 100

Question 25

duffy system frequencies

Answer 25

Fya: 60
Fyb: 75
Fy3: 100

Question 26

lutheran system frequencies

Answer 26

Lua: 5
Lub: 99

Question 27

units to test formula

Answer 27

(100*units needed)/(100-antigen frequency)

Question 28

what is on glycophorin A

Answer 28

• chromosome 4
• attaches M and N on the tail

Question 29

what is on glycophorin B

Answer 29

S or s at the bottom
slight N on ends
U at base

Question 30

what antigens are present in P1 phenotype

Answer 30

P1, P, Pk w/ no anti-P antibodies

Question 31

describe the action of P1Pk gene

Answer 31

transferase adding galactose to end of sugar of type 2 forms pk antigen
- in competition with H fucosyltransferase

Question 32

describe the glob gene

Answer 32

galactosaminyl transferase recognizing two galactoses to add a galnac => P antigen

Glob gene on chromosome 3

Question 33

compare I and i

Answer 33

• I: branched, adults
• i: linear, fetal

Question 34

describe auto anti-I

Answer 34

• most common cold agglutinin
• strong reaction with adults no reaction with fetal cells
• enhanced by poly-AHG

Question 35

describe P antibodies

Answer 35

• anti-P1: naturally occurring IgM
• anti-P1PL: naturally occuring in Pnull (IgG)

Question 36

what chromosome is Kell located

Answer 36

7

Question 37

Kell null syndrome name

Answer 37

Mcleod - acanthocytes

Question 38

role of XK

Answer 38

XK multipass protein with KX antigen

Question 39

describe big I

Answer 39

internal portion of type 2 chains
branchy, adult form
related to M. pneumonia

Question 40

describe little i

Answer 40

in infants, linear i
related to infectious mono

Question 41

describe anti-I

Answer 41

auto-anti-I causing cold agglutination
-> agglutinates only with m. pneumonia infection, otherwise undetectable

Question 42

describe anti-i

Answer 42

in infants after infectious mono infection