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1
Q

warm reactive

A

IgG

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2
Q

detectible at immediate spin

A

IgM

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3
Q

small enough to cross the placenta potentially causing HDFN

A

IgG

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4
Q

best at fixing compliment

A

IgM

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5
Q

first seen in the primary immune response

A

IgM

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6
Q

Which protein in the compliment system is identifiable on the red cell surface after compliment has been activated?

A

C3b

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7
Q

An antigen is expressed on the outside surface of the red cell. What does that mean for the patient gene

A

the patients gene codes for the allele of the specific antigen

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8
Q

True or False: Additive solutions increase the shelf life of red cell products by requiring the removal of plasma from the red cells.

A

false
- not all additive solutions require the removal of plasma

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9
Q

Which grade would you give to an agglutinate that has a single large chunk an several smaller chunks in the tube?

A

3+

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10
Q

Which blood group was named for the scientists who were researching an antibody that caused hemolytic disease of the newborn?

A

LW
- Landsteiner weiner were researching it and discorvered LW on accident but named it D, other scientists came and discovered the mistake and named the initial discovered antigen LW
- part of the RhAG complex for stabilization (decreases expression with age)

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11
Q

Which antigen in the Rh system has a significantly different (>20% different) antigen frequency in the Black US population vs the White US population?

A

big C
- black is more likely to have little c (98%) than big c (20%), white is 68% big C though little c is still more common at (80%)

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12
Q

Which genotype would a person have if they inherited RhD and Rhce genes from their mother and RhD and RhCe from their father?

A

R1R0

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13
Q

partial D antigen has a mutation on the ____ of the cell

A

outside

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14
Q

weak D antigen has a mutation on the protein on _____ of the cell

A

inside

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15
Q

A frameshift mutation in the RhD will result in a patient who is:

A

Rh negative
- will still have C/c and E/e but D will not be translated

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16
Q

True or False: a 4 month old baby who is Rh negative is expected to have anti-D in their plasma.

A

false
- anti-D is formed after immunizing event

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17
Q

what serological result is seen when you forgot to add plasma to IAT

A

negatives in AHG

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18
Q

what serological result is seen when you over wash in IAT

A

no button in AHG

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19
Q

what serological result is seen when you under wash in IAT

A

negative in CC phase

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20
Q

which class of Ab reacts best at room temp

A

IgM

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21
Q

IgG Ab are clinically significant for HDN because

A

they can cross the placenta

22
Q

hemolysis is a positive reaction that indicates you have most likely identified antibodies that
- react at AHG
- fix compliment
- cross the placenta
- are immune stimulated

A

fix compliment
- compliment ends in hemolysis

23
Q

which of the following is known as the membrane attack complex in the classical pathway

A

C5b,6,7,8,9

24
Q

as RBCs are stored which of the following increases
- plasma potassium
- 2,3-DPG
- ATP
- pH

A
  • plasma potassium
  • along with lactic acid and hgb as they are released from the cell and metabolism
25
what is the longest length of time that the FDA says red cells can be stored for
42 - additive solutions reduce hematocrits allowing less viscosity and easier infusion of packed RBCs while harvesting max plasma
26
when there is a shift to the left hgb affinity for oxygen does what
increases - holds oxygen tighter and does not release into tissues - 2,3 DPG will decrease as O2 takes its place on the hgb
27
what is the maximum time a sample may be obtained before a transfusion for pretransfusion testing
3 days
28
what does AB gene on chrom 9 code for
transferase to add either N-acetyl galactosamin (A) or galactose (B)
29
what does H gene code for
chrom 19 codes for fucose to be added to precursor substance to form H antigen
30
what does Se code fo
chrom 19 codes for fucose addition to precursor substance type 1 to make H substance
31
what is the most common cuase of anti A 3+mf and anti B 4+
transfusion - two populations of cells
32
aquired B antigen is found in which individuals
group A persons - part of N-acetylgalactosamine is cut off to resemble B antigen in infections
33
what subgroup is suspected with anti-B gives 1+mf and anti-AB 1+mf and A1 cell 3+
B3 - 3 subgroup = mixed field - reverse type for subgroups will still show normal reactivity
34
you would use Ulex europeaeus reagent to investigate what
potential bombay - specific for H antigen
35
which blood group has the most amount of H substance
O - O>A2>B>A2B>A1>A1B
36
if the patient with following results was a secretor, what substance would that person have in their secretions: Anti A: 0 anti B: 4+ A1 cell: 4+ B cell: 0
- B, Leb - secretor means terminal fucose is added, if patient has FUT 3 then they will make lewis B
37
the lewis gene codes for a transferase that transfers a sugar onto precursor substance, what is that sugar
fucose - places it in subterminal position
38
a patient has HH, LeLe, sese, A genes. what antigens will be expressed on their red cells
A, H, Lea - Lea since non secretor status means no terminal fucose is added to secretions and no Leb can be formed
39
which antibody reacts with Rhesus baby cells but not rhesus adult cells
anti - LW - expressed in higher amounts in babies and decreases with age
40
a patient has developed multiple Abs to the Rh system. Anti-D, anti-C, anti-E/ how many units are tested to find compatible blood
1 Rh negative unit - Rh negative is most likely to be dce so any Rh neg labelled bag should also be C and E neg (making it dce)
41
which genotype may demonstrate dosage with anti-C
R0r' - C in trans to D has an inhibitory effect - acts as antithetical pari - capellini effect
42
which offspring is not possible from a mother who is R1R2 and a father who is R1r
R2/R2 (DcE/DcE)
43
an individual has the following Rh phenotype: D+, C-, E+, c+, e- what is their most likely genotype if they are Asian
R2R2 (DcE/DcE)
44
how are weaker than average reactions with anti-D categorized for DONOR cells
Rh pos - a pos reaction is still pos and cannot give Rh pos to Rh neg
45
which op is the weak D test performed in
baby - needs to protect mother from immunizing event
46
which patient would you expect to make anti-D - pregnant pt w/ D mosaic - pt who gives weakly reactive D - pt who has made anti-c - pt who is immune comp and transfused Rh pos blood
pregnant with D mosaic (partial D) -=> forms antigens against full D
47
how is testing for Rh antigens and Ab diff from ABO testing
- ABO ANTIBODIES can be tested at room temp - Rh ANTIBODIES need AHG
48
which genotype shows the strongest reaction with anti-D
D--/D-- (exhalted D) - D masks CE during transcription and is translated instead and many more times
49
which enhancment colloid works by removal of water to concentrate antibody
polyethylene glycol (PEG)
50
which of the coombs tests does not require check cell addition to verify washing
gel - no check cells or wash

blood bank (16 decks)

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