ABX: MOA, MOR, Classes Flashcards Preview

Fall2014 - Pharm ID/Pulm > ABX: MOA, MOR, Classes > Flashcards

Flashcards in ABX: MOA, MOR, Classes Deck (23):
1

Which antibiotic classes inhibit cell wall formation?

-penicillins
-cephalosporins
-carbapenems
-monobactams

2

MOA of Vancomycin

inhibits cell wall formation at earlier step than beta-lactams

3

MOA of Fluoroquinolones

inhibit topoisomerases and DNA replication

4

MOA of TMP/SMX

-inhibit DNA, RNA, protein synthesis (blocks folate pathway)

5

Which antibiotic classes inhibit protein synthesis at the ribosomes?

-aminoglycosides
-tetracyclines
-clindamycin

6

MOA of Macrolides

-inhibit RNA-dependent protein synthesis

7

MOA of Metronidazole

-reactive metabolites damage DNA

8

Mech of Resistance of Penicillins

-beta lactamase
-altered penicillin binding proteins (PBPs)

9

Mech of Resistance of Cephalosporins

-beta lactamase
-altered penicillin binding proteins (PBPs)

10

Mech of Resistance of Carbapenem

antagonism with other beta lactams

11

Mech of Resistance of Vancomycin

-VRE/VRSA

12

Mech of Resistance of Fluoroquinolones

-efflux pump
-gene mutations
-decreased permeability

13

Mech of Resistance of TMP/SMX

gene mutations

14

Mech of Resistance of Aminoglycosides

-inactivation by enzymes
-decreased binding/uptake

15

Mech of Resistance of Tetracyclines

-decreased permeability
-efflux pump
-altered PBPs

16

What are the classes of penicillin antibiotics?

-Narrow spectrum/natural
-Penicillinase-resistant penicillins (anti-staph)
-Extended Spectrum:
Amino-penicillins (+ beta-lactamase inhibitors)
Anti-pseudomonal penicillins (+/- beta-lactamase inhibitors)

17

What are the classes of cephalosporin antibiotics?

1st-3rd generations

18

What are the classes of fluoroquinolone antibiotics?

1st-4th generations

19

What are the classes of macrolide antibiotics?

-Azithromycin
-Clarithromycin
-Erythromycin

20

Penicillin General Structure

-garage and house structure
(beta lactam ring and 5 side thiazolidine ring)

21

Cephalosporin General Structure

-garage and house with a porch
(beta lactam ring and 6 side dihydrothiazine ring)

22

Carbapenem General Structure

-garage and house w/ attic and clothesline
(beta lactam ring and 5 side carbapenem ring with long chain coming off the attic)

23

Fluoroquinolone General Structure

-3 hexagonal rings