ABX: Spectrum, Uses Flashcards Preview

Fall2014 - Pharm ID/Pulm > ABX: Spectrum, Uses > Flashcards

Flashcards in ABX: Spectrum, Uses Deck (20):
1

Spectrum of Activity: Narrow Spectrum/Natural Penicillins

**narrow, mostly G+**
-Strep, Enterococcus
-N. meningitidis
-Peptostrepto, Clostridium
-Treponema pallidum, Listeria

2

Spectrum of Activity: Penicillinase Resistant/Anti-Staph Penicillins

**narrow, mostly G+**
-MSSA, Streptococcus, MSSE
-Peptostrepto

3

Spectrum of Activity: Amino-Penicillins

**extended spectrum**
-Strep and Enterococcus
-H. flu, Neisseria, Proteus
-Peptostrepto, Clostridium
-Listeria, H. pylori

4

Spectrum of Activity: Amino-Penicillins w/ Beta-lactamase Inhibitor

**adds coverage for Staph, M. cat, E. coli, Klebsiella, B. frag**
-Strep, Entero
-H flu, Neisseria, Proteus
-Peptostrepto, Clostridium

5

Spectrum of Activity: Anti-Pseudomonal Penicillins

**similar to amino-pens, but add Pseudomonas**
-Staph, Strep, Entero
-H. flu, Neisseria, Proteus, M cat, E coli, Klebsiella, Proteus
-Peptostrepto, Clostridium

6

Spectrum of Activity: Anti-Pseudomonal Penicillins w/ Beta-lactamase Inhibitor

**adds coverage for Serratia, Enterobacter, B. frag**
-Staph, Strep, Entero
-H. flu, Neisseria, Proteus, M cat, E coli, Klebsiella, Proteus
-Peptostrepto, Clostridium

7

Spectrum of Activity: Cephalosporins

1st gen: G+ *****, G- **
2d gen: G+ ***, G- ****
3rd gen: G+ **, G- ******

8

Spectrum of Activity: Carbapenems

**broad spectrum ICU coverage**
-Staph, Strep
-good G- including Pseudomonas
-good anaerobes except C diff
-no coverage MRSA, DRSP, VRE, Enterococcus, atypical pneumonia

9

Spectrum of Activity: Monobactams

**Gram negative specialist**
-good activity against gram neg anaerobes, including Pseudomonas

10

Spectrum of Activity: Vancomycin

**Gram positive specialist**
-very active against Staph, HCA-MRSA, MRSE, Strep, Enterococcus
-no gram neg coverage

11

Spectrum of Activity: FQs

-Ciprofloxacin (2nd gen) is best pseudomonal
-Levofloxacin (3rd) is better resp FQ than cipro
-Moxifloxacin (4th) is best resp FQ, only one w/ B. frag activity
-all cover: chlamydia, legionella, mycoplasma, mycobacterium TB, H pulori

12

Spectrum of Activity: TMP/SMX

**varied**
-Strep pneumoniae, Staph
-H flu, M cat, E coli, Klebsiella, Serratia
-GI: Enterotoxigenic E coi, Salmonella, Shigella, Vibrio cholerae, Yersinia
-Listeria, Nocardia, Mycobacterium marinum
-Pneumocystis (carinii) jiroveci

13

Spectrum of Activity: Aminoglycosides

**good gram neg activity including Pseudomonas**
-tobramycin best for pseudomonas (Toby goes with Sue)
-gentamicin best for serratia (Gent goes with Serra)

14

Spectrum of Activity: Tetracyclines

**broad spectrum bacteriostatic drugs**
-inhibit many gram + and - organisms
-rickettsiae, spirochetes, mycoplasmas, chlamydiae, borrelia burgdorferi

15

Spectrum of Activity: Macrolides

-Erythro: varied G+, ok G-, Clostridium, mycoplasma/legionella/chlamydia species, Bordetella pertussis, Treponem, Campylobacter jejuni
-Clarithro: same as erythro but add toxoplasma gondii, borreli burgdorferi, babesia microti
-Azithro: broader spectrum; improved H flu; Peptostrepto and Clostridium; M and C pneumoniae, Treponema, N. gonorrhea, Chlamydia trachomatis

16

Spectrum of Activity: Clindamycin

**anaerobes and Gram positives**
-Staph, Strep
-B. frag, other Bacteroides, Clostridia, Peptostreptococcus
-P. acnes, Fusobacterium
-parasites: Gardnerella, Toxoplasmosis, PCP

17

Spectrum of Activity: Metronidazole

**anaerobes and parasites**
-Gm- anaerobes (Bacteroides) and some Gm+ (Clostridium)
-protozoa: Trichomonas, Giardia
-H. pylori

18

What abx has activity against Pneumocystis (carinii) jiroveci?

TMP/SMX

19

What abx (6) have activity against Pseudomonas?

-antipseudomonal penicillins +/- BLI
-3rd gen cephalosporins
-2nd gen FQ
-carbapenem
-aminoglycosides (tobramycin)

20

What abx (6) have activity against B. frag?

-amino pens with BLI
-antipseudomonal pens with BLI
-2nd gen cephalosporins
-4th gen FQ
-TCNs
-anti-anaerobes (clindamycin, metronidazole)