Flashcards in Misc Questions Deck (53):
Which drugs have an interaction with warfarin?
Which drugs are CI in pregnancy?
What are the common intracellular pathogens?
-3 types atypical pneumonia: Mycoplasma, Chlamydia, Legionella
Which abx classes have activity against intracellular pathogens?
Which abx require adjusted dosing for renal dysfunction?
-penicillins (except nafcillin)
-most cephs (except ceftriaxone)
-TCNs (except doxy and minocycline)
Describe vancomycin monitoring.
-peak trough levels
-obtain around 4th dose (both or trough only)
-10-15 mcg/mL recommended
-peak is controversial so many hospitals only do trough
Which abx class requires use of double coverage to treat Pseudomonas?
What drug is used in treatment of CF?
How is vancomycin administered and why?
-IV for systemic infections
-it is NOT absorbed via the GI tract
What are some ways to prevent vancomycin resistance?
Discouraged use in:
-prophylaxis for infection of vascular catheters
-eradication of MRSA/CA-MRSA
-primary tx for C diff
-routine prophylaxis for VLBW infants
-routine prophylaxis for peritoneal dialysis
What can be used to treat HCA-MRSA?
What can be used to treat CA-MRSA?
-mild to moderate: TMP/SMX, clindamycin, doxy
What can be used to treat VRE?
What drug interactions must be avoided with FQ use?
-chelation (decreased absorption) with metal cations eg antacids, iron salts (take 2 hrs before or after)
-any meds that prolong QT interval (moxifloxacin)
What drugs can get to the CSF?
What are aminoglycosides used in combination with and why?
-beta lactams affect bacterial cell wall
-weaker cell wall allows AGs to get in and affect protein synthesis
Which abx act on the 30S ribosome?
Which abx act on the 50S ribosome?
Which abx can be used to treat P. acnes?
-TCNs --> doxycycline
What is important to remember about erythromycin absorption?
-destroyed by gastric acid
-food decreases absorption
Which drugs may cause QT prolongation and must be administered carefully?
-macrolides and FQs
Which abx has C. diff as a potential adverse effect?
What drug has a bad interaction w/ EtOH and what happens?
-get a build up of acetaldehyde
-causes nausea and flushing
-no EtOH during tx or 3 days after
What is the chief avoidable cause of illness and death in the US?
What is the most common infectious cause of death in the US?
community acquired pneumonia
What are the top 2 nosocomial infections in the US?
What 2 drugs are used to treat Enterococcus?
IV ampicillin and gentamicin
Which macrolide has the highest bioavailability?
What are three respiratory FQs?
What is the dosage for an oral prednisone burst for COPD exacerbation?
40 mg PO qday x5 days
What are the options for H. pylori treatment?
What is used to treat Trichomoniasis?
Which abx require pharmacokinetic monitoring? Why?
vancomycin and AGs
due to ototoxicity and nephrotoxicity side effects
What is the FQ of choice for Pseudomonas?
Which macrolide has the most significant drug interactions?
Which macrolide has the fewest significant drug interactions?
Common Cervicitis/Proctitis/Urethritis Pathogens
Neisseria and Chlamydia
In asthma treatment, what are thrush, dysphonia and coughing side effects of?
What are the 4th generation cephalosporins?
What asthma intervention prevents inflammation but does not treat it?
Leukotriene modifiers (Singulair/Montelukast)
What treatment can be used for nighttime asthma sxs or with prolonged exercise?
What is the treatment for atypical pneumonia?
resp FQs (eg moxifloxacin)
What disease is caused by Rickettsiae?
Rocky Mtn Spotted Fever
What drug has good Gm+ and anaerobe coverage?
For a decreased asthma response to PRN SABA, what is the treatment?
prednisone burst 3-10 days
Red Neck Syndrome is a side effect of what drug?
Which cephalosporin has activity against MRSA?
What is indicated in Tx and Px of influenza A and B?
Oseltamivir and Zanamivir
Which cephalosporins has pseudomonas activity?
Which drug is most likely to cause seizures?
Which antibiotic has no absorption when given orally? What is the only indication for giving this drug orally?
-c diff if it is unresponsive to metronidazole
What is essential therapy for persistent asthma?
ICS and PRN SAB2A