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HEMATOLOGY (HARR) > Acute leukemias > Flashcards

Acute leukemias Flashcards

1
Q

Auer rods may be seen in all of the following
except:
A. Acute myelomonocytic leukemia (M4)
B. Acute lymphoblastic leukemia
C. Acute myeloid leukemia without maturation (M1)
D. Acute promyelocytic leukemia (M3)

A

B

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2
Q

Which type of anemia is usually present in a
patient with acute leukemia?
A. Microcytic, hyperchromic
B. Microcytic, hypochromic
C. Normocytic, normochromic
D. Macrocytic, normochromic

A

C

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3
Q

In leukemia, which term describes a peripheral
blood finding of leukocytosis with a shift to the
left, accompanied by nucleated red cells?
A. Myelophthisis
B. Dysplasia
C. Leukoerythroblastosis
D. Megaloblastosis

A

C

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3
Q

Which type of anemia is usually present in a
patient with acute leukemia?
A. Microcytic, hyperchromic
B. Microcytic, hypochromic
C. Normocytic, normochromic
D. Macrocytic, normochromic

A

C

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3
Q

The basic pathophysiological mechanisms
responsible for producing signs and symptoms in
leukemia include all of the following except:
A. Replacement of normal marrow precursors by
leukemic cells causing anemia
B. Decrease in functional leukocytes causing
infection
C. Hemorrhage secondary to thrombocytopenia
D. Decreased erythropoietin production

A

D

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4
Q

In leukemia, which term describes a peripheral
blood finding of leukocytosis with a shift to the
left, accompanied by nucleated red cells?
A. Myelophthisis
B. Dysplasia
C. Leukoerythroblastosis
D. Megaloblastosis

A

C

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5
Q

Which type of acute myeloid leukemia is called
the true monocytic leukemia and follows an acute
or subacute course characterized by monoblasts,
promonocytes, and monocytes?
A. Acute myeloid leukemia, minimally differentiated
B. Acute myeloid leukemia without maturation
C. Acute myelomonocytic leukemia
D. Acute monocytic leukemia

A

D

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6
Q

In which age group does acute lymphoblastic
leukemia occur with the highest frequency?
A. 1–15 years
B. 20–35 years
C. 45–60 years
D. 60–75 years

A

A

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7
Q

In which age group does acute lymphoblastic
leukemia occur with the highest frequency?
A. 1–15 years
B. 20–35 years
C. 45–60 years
D. 60–75 years

A

A

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8
Q

In which age group does acute lymphoblastic
leukemia occur with the highest frequency?
A. 1–15 years
B. 20–35 years
C. 45–60 years
D. 60–75 years

A

A

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9
Q

Disseminated intravascular coagulation (DIC) is
most often associated with which of the following
types of acute leukemia?
A. Acute myeloid leukemia without maturation
B. Acute promyelocytic leukemia
C. Acute myelomonocytic leukemia
D. Acute monocytic leukemia

A

B

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10
Q

An M:E ratio of 10:1 is most often seen in:
A. Thalassemia
B. Leukemia
C. Polycythemia vera
D. Myelofibrosis

A

B

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11
Q

Which of the following is a characteristic of
Auer rods?
A. They are composed of azurophilic granules
B. They stain periodic acid–Schiff (PAS) positive
C. They are predominantly seen in chronic
myelogenous leukemia (CML)
D. They are nonspecific esterase positive

A

A

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12
Q

SITUATION: The following laboratory values
are seen:
WBCs = 6.0 × 109/L Hgb = 6.0 g/dL
RBCs = 1.90 × 1012/L Hct = 18.5%
Platelets = 130 × 109/L
Serum vitamin B12 and folic acid: normal

These results are most characteristic of:
A. Pernicious anemia
B. Acute myeloid leukemia without maturation
C. Acute erythroid leukemia
D. Acute myelomonocytic leukemia

A

C

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13
Q

A 24-year-old man with Down syndrome presents
with a fever, pallor, lymphadenopathy, and
hepatosplenomegaly. His CBC results are as
follows:
WBCs = 10.8 × 109/L RBCs = 1.56 × 1012/L
8% PMNs Hgb = 3.3 g/dL
25% lymphocytes Hct = 11%
67% PAS-positive blasts Platelets = 2.5 × 109/L

These findings are suggestive of:
A. Hodgkin’s lymphoma
B. Myeloproliferative disorder
C. Leukemoid reaction
D. Acute lymphocytic leukemia

A

D

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14
Q

SITUATION: A peripheral smear shows 75%
blasts. These stain positive for both Sudan Black B
(SBB) and peroxidase. Given these values, which
of the following disorders is most likely?
A. Acute myelocytic leukemia (AML)
B. CML
C. Acute undifferentiated leukemia (AUL)
D. Acute lymphocytic leukemia (ALL)

A

A

15
Q

In myeloid cells, the stain that selectively identifies
phospholipid in the membranes of both primary
and secondary granules is:
A. PAS
B. Myeloperoxidase
C. Sudan Black B stain
D. Terminal deoxynucleotidyl transferase (TdT)

A

C

16
Q

Sodium fluoride may be added to the naphthyl
ASD acetate (NASDA) esterase reaction. The
fluoride is added to inhibit a positive reaction
with:
A. Megakaryocytes
B. Monocytes
C. Erythrocytes
D. Granulocytes

A

B

17
Q

Leukemic lymphoblasts reacting with anti-CALLA
are characteristically seen in:
A. B-cell ALL
B. T-cell ALL
C. Null-cell ALL
D. Common ALL

A

D

18
Q

Which of the following reactions are often positive
in ALL but are negative in AML?
A. Terminal deoxynucleotidyl transferase and PAS
B. Chloroacetate esterase and nonspecific esterase
C. Sudan Black B and peroxidase
D. New methylene blue and acid phosphatase

A

A

19
Q

A patient’s peripheral blood smear and bone
marrow both show 70% blasts. These cells are
negative for Sudan Black B stain. Given these data,
which of the following is the most likely diagnosis?
A. Acute myeloid leukemia
B. Chronic lymphocytic leukemia
C. Acute promyelocytic leukemia
D. Acute lymphocytic leukemia

A

D

20
Q

Which of the following leukemias are included in
the 2008 World Health Organization classification
of myeloproliferative neoplasms?
A. Chronic myelogenous leukemia (CML)
B. Chronic neutrophilic leukemia (CNL)
C. Chronic eosinophilic leukemia (CEL)
D. All of these options are classified as

A

D

21
Q

In addition to morphology, cytochemistry, and
immunophenotyping, the WHO classification of
myelo- and lymphoproliferative disorders is based
upon which characteristic?
A. Proteomics
B. Cytogenetic abnormalities
C. Carbohydrate-associated tumor antigen
production
D. Cell signaling and adhesion markers

A

B

22
Q

The WHO classification requires what percentage
for the blast count in the blood or bone marrow
for the diagnosis of AML?
A. At least 30%
B. At least 20%
C. At least 10%
D. Any percentage

A

B

23
Q

What would be the most likely designation
by the WHO for the FAB AML M2 by the
French–American–British classification?
A. AML with t(15;17)
B. AML with mixed lineage
C. AML with t(8;21)
D. AML with inv(16)

A

C

24
Q

What would be the most likely designation
by the WHO for the FAB AML M2 by the
French–American–British classification?
A. AML with t(15;17)
B. AML with mixed lineage
C. AML with t(8;21)
D. AML with inv(16)

A

C

25
Q

What would be the most likely designation
by the WHO for the FAB AML M3 by the
French–American–British classification?
A. AML with t(15;17)
B. AML with mixed lineage
C. AML with t(8;21)
D. AML with inv(16)

A

A

26
Q

Which AML cytogenetic abnormality is associated
with acute myelomonocytic leukemia with marrow
eosinophilia under the WHO classification of
AML with recurrent genetic abnormalities?
A. AML with t(15;17)
B. AML with mixed lineage
C. AML with t(8;21)
D. AML with inv(16)

A

D

27
Q

What would be the most likely classification
by the WHO for the FAB AML M7 by the
French–American–British classification?
A. Acute myeloid leukemias with recurrent genetic
abnormalities
B. Acute myeloid leukemia with multilineage
dysplasia
C. Acute myeloid leukemia not otherwise
categorized
D. Acute leukemias of ambiguous lineage

A

C

HEMATOLOGY (HARR) (11 decks)

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