Coagulation System Disorders Flashcards by Kathleen Glorioso

The APTT is sensitive to a deficiency of which
clotting factor?
A. Factor VII
B. Factor X
C. PF3
D. Calcium

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Which test result would be normal in a patient
with dysfibrinogenemia?
A. Thrombin time
B. APTT
C. PT
D. Immunologic fibrinogen level

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Which test result would be normal in a patient
with dysfibrinogenemia?
A. Thrombin time
B. APTT
C. PT
D. Immunologic fibrinogen level

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A patient with a prolonged PT is given intravenous
vitamin K. The PT corrects to normal after
24 hours. What clinical condition most likely
caused these results?
A. Necrotic liver disease
B. Factor X deficiency
C. Fibrinogen deficiency
D. Obstructive jaundice

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Which factor deficiency is associated with a
prolonged PT and APTT?
A. X
B. VIII
C. IX
D. XI

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Which factor deficiency is associated with a
prolonged PT and APTT?
A. X
B. VIII
C. IX
D. XI

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A prolonged APTT is corrected with factor
VIII– deficient plasma but not with factor
IX–deficient plasma. Which factor is deficient?
A. V
B. VIII
C. IX
D. X

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A prolonged APTT is corrected with factor
VIII– deficient plasma but not with factor
IX–deficient plasma. Which factor is deficient?
A. V
B. VIII
C. IX
D. X

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Which of the following is a characteristic of classic
hemophilia A?
A. Prolonged bleeding time
B. Autosomal recessive inheritance
C. Mild to severe bleeding episodes
D. Prolonged PT

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Refer to the following results:
PT = prolonged
APTT = prolonged
Platelet count = decreased
Which disorder may be indicated?
A. Factor VIII deficiency
B. von Willebrand’s disease
C. DIC
D. Factor IX deficiency

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Which of the following is a predisposing condition
for the development of DIC?
A. Adenocarcinoma
B. Idiopathic thrombocytopenic purpura (ITP)
C. Post-transfusion purpura (PTP)
D. Heparin-induced thrombocytopenia (HIT

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Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis

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Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis

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Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis

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The following results were obtained on a patient:
normal platelet count and function, normal PT,
and prolonged APTT. Which of the following
disorders is most consistent with these results?
A. Hemophilia A
B. Bernard–Soulier syndrome
C. von Willebrand’s disease
D. Glanzmann’s thrombasthenia

The following laboratory results were obtained
from a 40-year-old woman: PT = 20 sec; APTT =
50 sec; thrombin time = 18 sec. What is the most
probable diagnosis?
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor X deficiency
D. Hypofibrinogenemia

When performing a factor VIII activity assay, a
patient’s plasma is mixed with:
A. Normal patient’s plasma
B. Factor VIII deficient plasma
C. Plasma with a high concentration of factor VIII
D. Normal control plasma

The most suitable product for treatment of factor
VIII deficiency is:
A. Fresh frozen plasma
B. Factor VIII concentrate
C. Prothrombin complex concentrate
D. Factor V Leiden

Which of the following is associated with an
abnormal platelet aggregation test?
A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Afibrinogenemia

Refer to the following results:
PT = normal
APTT = prolonged
Bleeding time= increased
Platelet count = normal
Platelet aggregation to ristocetin = abnormal
Which of the following disorders may be
indicated?
A. Factor VIII deficiency
B. DIC
C. von Willebrand’s disease
D. Factor IX deficiency

Which results are associated with hemophilia A? A. Prolonged APTT, normal PT B. Prolonged PT and APTT C. Prolonged PT, normal APTT D. Normal PT and APTT

Fibrin monomers are increased in which of the following conditions? A. Primary fibrinolysis B. DIC C. Factor VIII deficiency D. Fibrinogen deficiency

Which of the following is associated with multiple factor deficiencies? A. An inherited disorder of coagulation B. Severe liver disease C. Dysfibrinogenemia D. Lupus anticoagulant

Normal PT and APTT results in a patient with a poor wound healing may be associated with: A. Factor VII deficiency B. Factor VIII deficiency C. Factor XII deficiency D. Factor XIII deficiency

Fletcher factor (prekallikrein) deficiency may be associated with: A. Bleeding B. Thrombosis C. Thrombocytopenia D. Thrombocytosis

One of the complications associated with a severe hemophilia A is: A. Hemarthrosis B. Mucous membrane bleeding C. Mild bleeding during surgery D. Immune-mediated thrombocytopenia

The most common subtype of classic von Willebrand’s disease is: A. Type 1 B. Type 2A C. Type 2B D. Type 3

A patient with a prolonged PT is given intravenous vitamin K. The PT corrects to normal after 24 hours. What clinical condition most likely caused these results? A. Necrotic liver disease B. Factor X deficiency C. Fibrinogen deficiency D. Obstructive jaundice

A prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient? A. VIII B. V C. XI D. IX