Addiction

Question 1

Nicotinic AcH R partial agonist

Management of tobacco use

Answer 1

Varenicline

Question 2

Atypical Antidepressant
MOA: inhibits uptake of NE and DA
stabilizes DA levels following tobacco withdrawal.

Answer 2

Buproprion

Question 3

Mu opioid full agonist
Management of opiate abuse
MOA: agonist approach to prevent withdrawal

Answer 3

Methadone

Question 4

Opioid receptor antagonist
Management of opiate abuse
MOA: blocking opioid receptors at the neurobiological targets.
Blocks drugs rewarding effects

Answer 4

Naltrexone

Question 5

Alpha 2 agonist
MOA: decreases sympathetic activity by stimulating alpha 2 receptors
Management of opiate abuse
Masks withdrawal effects

Answer 5

Clonidine

Question 6

GABA agonist
Management of alcohol abuse
Facilitates GABA binding to GABAa
Long acting sedative

Answer 6

Diazepam

Question 7

Anti seizure
Management of alcohol abuse
Prolongs Na+ inactivation

Answer 7

Carbamazepine

Question 8

Inhibits acetaldehyde dehydrogenase
Management of alcohol abuse
Blocks conversion of acetaldehyde to acetate.
Flushing, headache, nausea, dysphoria

Answer 8

Disulfiram

Question 9

Opioid receptor antagonist
Management of alcohol abuse
Block endogenous reward systems.

Answer 9

Naltrexone

Question 10

These two drugs are both hepatotoxic and should not be given to patients with live dysfunction:

Answer 10

Dilsufiram

Naltexone