Chemotherapy and Cancer drugs Flashcards
(12 cards)
DNA damaging agent Alkylating agent Mutagenic (carcinogenic) Phase non-specific MOA: covalent linkages
Dacarbazine
DNA damaging agent
Anti-tumor antibiotic
MOA: Binds to DNA and prevents strand passage and relegation (joining) By topoisomerase II–> apoptosis
Phase nonspecific
Doxorubicin
DNA damaging agent
Anti-tumor antibiotic
MOA: Binds to DNA and chelates iron, accumulating free radicals, causing DNA breakage–> apoptosis
Phase Non specific
Bleomycin
Microtubule Inhibitor
Vinca Alkaloid
MOA: Binds to Beta and Alpha tubule–> prevents spindle formation.
M Phase specific
Vinblastine
Anti-metabolite (purine antagonist)
Inhibitor of DNA synthesis
S phase specific
Inserts into DNA: DNA chain termination, DNA breakage, inhibits cell growth.
Thioguanine
Folate analog
Inhibitor of DNA synthesis
S phase specific
Inhibits DHFR conversion of dihydrofolate into tetrahydrofolate.
Give lethal dose of this drug followed by folinic acid.
Methotrexate
Topoisomerase inhibitor
Inhibitor of DNA synthesis
S phase specific
Camptothecin analog inhibits topoisomerase I
Topotecan
Anti-angiogenic drug
Prevent tumor metastases
MOA: inhibits tumor blood vessel growth and can prolong survival in cancer pts.
Bevacizumab
SERM
Hormone agonist/antagonist
Prevention of BC in women
MOA: Selective estrogen receptor modulator; inhibits estrogen receptors in breast tissue and inhibits production of growth promoting proteins.
Partial against at receptors in endometrium
Increase risk for endometrial cancer
Tamoxifen
Vaccine
Prevents type 16,18, 6, and 11 HPV
Gardisil
Kinase Inhibitor
Very selective, targeting oncogene products
Used for Chronic myeloid leukemia
Lower toxicity
Imatinib
4 drugs used in combo therapy:
Dacarbazine
Doxorubicin
Bleomycin
Vinblastine
