GI drugs

Question 1

1st line treatment for ulcers:

Treats GERD

Answer 1

Omeprazole
Iansoprazole
(both proton pump inhibitors)

Question 2

Histamine receptor antagonists
Inhibits acid production by clocking H2 receptors on parietal cells.
Treats GERD

Answer 2

Cimetidine (drug interaction with warfarin and theophylline)

Famotidine (no iteractions)

Question 3

Prostaglandin analog
cannot give to pregnant women
Binds to and actives EP3 receptors–> increases bicarb, inhibits histamine.

Answer 3

Misoprostol

Question 4

Anti-histamine
Tx of motion sickness
Limits stimulation of vomiting center.
Inhibits H1 receptor:

Answer 4

Dimenhydrinate

Question 5

Anti-cholinergic
Tx of motion sickness
Limit stimulation of vomiting center
Inhibit muscarinic receptor.
Side effects: dry mouth, urinary retention, blurred vision

Answer 5

Scopolamine

Question 6

Serotonin receptor antagonist
Tx of visceral nausea
Block 5HT3 receptors in small bowel
Reduce emetic signals

Answer 6

Ondansetron

Question 7

Dopamine receptor antagonists
Blocks D2 like DA receptors
Extensive side effects: sedation, orthostatic hypotension, tar dive dyskinesia.

Answer 7

Promethazine

Chlorpromazine