Reproductive Drugs

Question 1

MOA: Inhibit secretion of LH and FSH.

Side Effects: high risk for endometrial cancer.

Answer 1

Ethinyl estradiol (estrogen)

Question 2

MOA: Inhibit secretion of LH and FSH.
MOA: Act at androgen receptors–> masculinization effects.

Answer 2

Levonorgestrel (synthetic progestin)

Question 3

Clinical use: Extended preparation: 91 days on, 7 days off.

Side Effect: Increased risk for breakthrough bleeding.

Answer 3

Seasonal/Seasonique

Question 4

Clinical Use: Continuous prep: 365 days on–> no periods

Side Effect: Increased risk for breakthrough bleeding.

Answer 4

Lybrel

Question 5

Used because it has lower occurrence of acne, PMS, weight gain, and hirsutism.
MOA: Agonist at progesterone receptors.
MOA: Blocks mineralocorticoid and androgen receptors.
Side Effect: increase risk for venous thromboembolism.

Answer 5

Drospirenone (progestin)

Question 6

Luteolytic drug. Given with prostaglandins to terminate pregnancy.
MOA: Antagonist at progesterone and glucocorticoid receptors.

Answer 6

Mifepristone (RU-486 abortion drug)

Question 7

High dose levonorgestrel

Answer 7

Plan B

Question 8

Selective estrogen receptor modulator–> Stimulates gonadotropin (FSH and LH) relate by blocking negative feedback.

Answer 8

Clomiphene (fertility drug)

Question 9

Analog of GnRH–> Stimulates gonadotropin release

Answer 9

Gonadorelin (fertility drug)

Question 10

Analogs of LH and/or FSH:

Answer 10

Gonadotropins (hCG) (Fertility drug)

Question 11

Primary tx for vasomotor symptoms.
Conjugated estrogen, purified from urine of pregnant horses.
Increased risk for venous thrombosis and stroke.
Increase risk for endometrial cancer in non hysterectomized women:

Answer 11

Premarin (HRT)

Question 12

Primary tx for vasomotor symptoms.
Estrogen + Progestin
Increase risk of CHD, venous thrombosis, breast cancer.
Reduced osteoporosis, hot flashes and incidence of colorectal cancer.

Answer 12

Prempro (HRT)

Question 13

Alpha-1 selective antagonist
1st line tx for BPH.
Relieves LUTS.

Answer 13

Tamsulosin

Question 14

Nonselective alpha antagonist.
1st line tx for BPH.
Relaxes vascular smooth muscle, but everywhere!
Side effect: Hypotension

Answer 14

Doxazosin

Question 15

5- alpha reductase inhibitor (prevents conversion of testosterone to active DHT).
BPH: decreases size of prostate but doesn’t alleviate LUTS.

Answer 15

Dutasteride

Question 16

PDE-5 Inhibitors
Prevents conversion of cGMP to inactive form
Treat ED.

Answer 16

SildenaFIL
VardeaFIL
TadalaFIL