Adenoviridae

Question 1

T/F: Adenoviruses are non-enveloped with a hexagonal outline

Answer 1

True

Question 2

What is a very characteristic morphological feature of adenoviruses?

Answer 2

12 vertex penton capsomers each with a fiber protrude from capsid surface

Question 3

Adenoviruses have intranuclear inclusion bodies that contain large numbers of what?

Answer 3

Virions

Question 4

Since adenoviruses have penton fibers, what can they do to RBCs?

Answer 4

Agglutinate RBCs

Question 5

T/F: most adenoviruses have wide host range

Answer 5

False, have narrow host ranges

Question 6

What two diseases do many adenoviruses cause?

Answer 6

1. Acute respiratory disease

2. Gastroenteric disease

Question 7

Adenoviruses interfere wit the immune system, causing what?

Answer 7

Immunosuppression

Question 8

T/F: Adenoviruses can establish long periods of latency

Answer 8

True.

Question 9

T/F: under certain conditions, adenoviruses can be oncogenic

Answer 9

True

Question 10

What are the two important genera of adenoviruses?

Answer 10

1. Mastadenovirus (mammalian adenoviruses)

2. Aviadenovirus (avian adenoviruses)

Question 11

T/F: In avian adenoviruses, each penton fiber is bifurcated and appears as two fibers

Answer 11

True

Question 12

What causes infectious canine hepatitis (ICH)?

Answer 12

Canine adenovirus 1 (CAV1)

Question 13

After an acute infection, CAV1 sheds in what for 6-9 months?

Answer 13

Sheds in urine for 6-9 months

Question 14

What is the transmission route for CAV1?

Answer 14

Oronasal transmission

Question 15

What is the source of infection for CAV1?

Answer 15

Secretions/excretions of infected dog
Contaminated fomites
Ectoparasites

Question 16

What 4 organs are the main targets organs for CAV1?

Answer 16

Liver, kidneys, spleen, and lungs

Question 17

T/F: The antibody titer of a dog is very crucial for infectious canine hepatitis caused by CAV1

Answer 17

True

Question 18

T/F: in chronic cases with infectious canine hepatitis, cirrhosis can occur

Answer 18

True

Question 19

T/F: In acute or chronic cases of infectious canine hepatitis, glomerulonephritis can occur

Answer 19

True

Question 20

What ocular lesion is seen in dogs during recovery or chronic cases of infections canine hepatitis?

Answer 20

Corneal edema (blue eye)

Question 21

T/F: An increase in CAV1 antibody production and formation of viral-antibody immune complexes contributes to the formation of corneal edema

Answer 21

True

Question 22

T/F: Compliment activation and neutrophil chemotaxis causes extensive damage to corneal epithelium, which will disrupt the intact corneal epithelium and allow aqueous humor to enter cornea

Answer 22

True

Question 23

T/F: Accumulation of edematous fluid w/in cornea stroma results inn corneal edema

Answer 23

True

Question 24

What are two complications of infectious canine hepatitis?

Answer 24

1. Disseminated intravascular coagulation (DIC) resulting from damage to endothelium
2. Bacterial pyelonephritis resulting from renal damage

Question 25

Infectious canine hepatitis CS are observed in dogs of what age group?

Answer 25

Less than 1 year of age

Question 26

Which leads to death quicker: peracute or acute cases of ICH?

Answer 26

Peracute

Question 27

What are some general CS of acute ICH?

Answer 27

Depression, anorexia, vomiting, fever, abdominal pain/tenderness, hepatomegaly, jaundice, swollen lymph nodes, subQ edema

Question 28

T/F: Icterus is common in early acute phase of ICH

Answer 28

False, it is uncommon

Question 29

T/F: corneal edema and anterior uveitis occur when clinical signs of ICH begins

Answer 29

True

Question 30

T/F: During necropsy and histopathology, paint-brush hemorrhages, centrilobular liver necrosis, and grey/white foci on kidney can be seen

Answer 30

True

Question 31

What two Dx methods are important in ICH?

Answer 31

Biochemistry and hematology

Question 32

Virus isolation for ICH is mainly done with what body fluid?

Answer 32

Urine

Question 33

What is the vaccine of choice for ICH?

Answer 33

CAV2 attenuated live virus strain

Question 34

T/F: Maternal Ab's do not interfere with active immunization of puppies

Answer 34

False, they do interfere with puppies until they are 9-12 weeks of age

Question 35

Canine infectious tracheobronchitis (CITB) is commonly referred to as what?

Answer 35

Kennel cough

Question 36

What is the main cause of kennel cough (CITB)?

Answer 36

Canine adenovirus 2 (CAV2)

Question 37

With ITB is life threatening: uncomplicated or complicated ITB?

Answer 37

Complicated ITB

Question 38

What is the Tx plan for kennel cough?

Answer 38

Antitussives in combo with bronchodilators

Question 39

What are two types of equine adenoviruses?

Answer 39

Equine adenoviruse 1 and 2 (EAV1 and EAV2)

Question 40

Which equine adenovirus is associated with SCID in foals?

Answer 40

EAV1

Question 41

What are the CS in SCID foals?

Answer 41

Severe bronchiolitis and pneumonia Respiratory distress

Question 42

What disease does avian adenovirus cause in chickens?

Answer 42

Inclusion body hepatitis egg drop syndrome '76

Question 43

What disease does avian adenovirus cause in ducks?

Answer 43

Hepatitis (rare)

Question 44

What disease does avian adenovirus cause in quail?

Answer 44

Bronchitis

Question 45

What disease does avian adenovirus cause in turkeys?

Answer 45

Hemorrhagic enteritis egg drop syndrome

Question 46

What disease does avian adenovirus cause in pheasants?

Answer 46

Marble spleen disease