Herpesviridae Part 1

Question 1

What is the virus morphology of herpesviridae?

Answer 1

Enveloped, spherical to pleomorphic; with double stranded DNA

Question 2

T/F: herpesviruses survive well outside host

Answer 2

False, do not survive well outside host

Question 3

Who serve as a reservoir for transmission of herpesviruses?

Answer 3

Latently infected animals

Question 4

What is a histological characteristic of herpesviruses?

Answer 4

Eosinophilic intranuclear inclusion bodies knows as type A cowdry bodies

Question 5

What are the two important subtypes of bovine herpesvirus 1 (BHV1)

Answer 5

1. BHV 1.1 (respiratory subtype)

2. BHV 1.2 (genital subtype)

Question 6

Where are the sites of latency for BHV1?

Answer 6

1. Trigeminal nerve: respiratory subtype

2. Sciatic nerve: genital subtype

Question 7

What are the CS of the respiratory form of BHV1?

Answer 7

Red nose, necrotic rhinitis, dust pneumonia

Question 8

T/F: IBR lesions are confined to the conjunctiva and no lesions are on the cornea, except diffuse edema

Answer 8

True

Question 9

T/F: Abortions caused by BHV1 are often preceded by pustular vulvovaginitis

Answer 9

True

Question 10

What are the 2 genital diseases caused by BHV1 in bovine?

Answer 10

1. IPV (infectious pustular vaginitis)

2. Balanoposthitis

Question 11

T/F: the paranteral vaccine for BHV1 is safe to used in pregnant cows

Answer 11

False, it causes abortion; the intranasal vaccine is safe to use in pregnant cows

Question 12

What 2 infections does BHV2 cause?

Answer 12

1. Bovine ulcerative mammillitis

2. Pseudo-lumpy skin disease

Question 13

What are the two transmission routes of bovine ulcerative mammillitis caused by BHV2?

Answer 13

1. Direct contact and vomited mediated

2. Mechanical transmission

Question 14

T/F: in bovine ulcerative mammillitis caused by BHV2, there is a high incidence of mastitis

Answer 14

True

Question 15

What infections does porcine herpesvirus 1/suid herpesvirus 1 cause?

Answer 15

Pseudorabies

Question 16

Who are the primary reservoirs for pseudorabies caused by PHV1?

Answer 16

1. Primarily recovered pigs

2. Rodents also

Question 17

T/F: Pseudorabies is shed in urine and feces

Answer 17

False; shed in saliva, nasal discharge and milk of infected pigs

Question 18

Who are the secondary hosts that pseudorabies can be transmitted to?

Answer 18

1. Dogs and cats via ingestion of infected pig

2. Cattle via direct contact

Question 19

What is the primary site of viral replication for pseudorabies?

Answer 19

Upper respiratory tract

Question 20

What are the CNS lesions of pseudorabies?

Answer 20

1. Ganglioneuritis
2. Nonsuppurative meningoencephalitis
3. Perivascular cuffing

Question 21

T/F: Pruritis (itching) is a dominant feature in primary hosts with pseudorabies

Answer 21

False, in secondary hosts

Question 22

T/F: piglets born to non-immune sows are most susceptible to pseudorabies and will show signs of CNS disease

Answer 22

True

Question 23

In cattle, a secondary host to pseudorabies, what CS are seen?

Answer 23

Intense pruritis, frenzy, death from resp. failure

Question 24

What are the CS of dogs, a secondary host to pseudorabies?

Answer 24

Frenzy and pruritis, self mutilation, drooling

Question 25

T/F: Cats, a secondary host of pseudorabies, pruritis may not be observed bc of rapid disease progression

Answer 25

True

Question 26

T/F: Vaccinations for pseudorabies can prevent infection

Answer 26

False, they reduce losses in enzootic areas and alleviate CS in pigs of certain ages

Question 27

What are two types of equine herpesviruses?

Answer 27

1. Equine herpes virus 1 (EHV1) | 2. Equine herpes virus 4 (EHV4)

Question 28

Which equine herpes virus is the most virulent?

Answer 28

EHV 1

Question 29

What two locations can a latent EHV 1 reside in?

Answer 29

CNS and lymph system

Question 30

What is the principle route of EHV1 infection?

Answer 30

Respiratory tract

Question 31

What is the main pathogenesis of EHV1?

Answer 31

Immunosuppression

Question 32

T/F: EHV1 can cause encephalomyelopathy (EHM) in horses of any age and breed

Answer 32

True

Question 33

The majority of abortions caused by EHV1 occurs during what stage of pregnancy

Answer 33

Last trimester

Question 34

What disease does EHV4 cause?

Answer 34

Equine viral rhinopneumonitis

Question 35

T/F: EHV 4 causes more severe tissue destruction than EHV1

Answer 35

False, causes less severe tissue destruction

Question 36

T/F: EHV4 rarely causes abortion when in infects pregnant mares

Answer 36

True

Question 37

T/F: EHV4 usuallly results in viremia

Answer 37

False, rarely results in viremia

Question 38

What kind of vaccines are available for EHV?

Answer 38

Live attenuated and inactivated commercial EHV 1 vaccine and combined product with EHV1 and EHV 4