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Adrenergic Pharm Flashcards

(52 cards)

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1
Q

epinephrine

A

Alpha1, beta 1, and beta 2 activator

Short half life

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2
Q

Norepinephrine

A

Alpha 1 and beta 1 activator
little effect on beta 2
Short half life

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3
Q

Isoproterenol

A

Potential non-selective beta-receptor agonist

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4
Q

Dopamine

A

Actives D1 receptors in renal vasculature

Increases renal blood flow

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5
Q

Dobutamine

A

Relatively beta1-selective

Short half life

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6
Q

Phenylephrine

A

Prototypic alpha1 agonist

Mydriatic and decongestant

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7
Q

Methoxamine

A

Alpha1 selective agonist

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8
Q

Ephedrine

A

First orally active sympathomimetic drug

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9
Q

Pseudoephedrine

A

OTC decongestant

Indirectlyreleases endogenous NE

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10
Q

Oxymetazoline

A

Direct alpha1 agonist

Topical decongestant

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11
Q

Xylometazoline

A

Direct alpha1 agonist

Topical decongestant

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12
Q

Clonidine

A

Alpha2 selective agonist

Anti hypertensives

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13
Q

Methyldopa

A

Alpha2 selective agonist
Anti hypertensives
Used in pregnancy

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14
Q

Guanfacine

A

Alpha2 selective agonist

Anti hypertensives

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15
Q

Guanabenz

A

Alpha2 selective agonist

Anti hypertensives

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16
Q

Prenalterol

A

Beta1 selective partial agonist

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17
Q

Albuterol

A

Beta2 selective agonist

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18
Q

Salmeterol

A

Beta2 selective agonist

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19
Q

Terbutaline

A

Beta2 selective agonist

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20
Q

Ritodine

A

Beta2 selective agonist

Used for uterine relaxation in premature labor

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21
Q

Amphetamine

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A

Indirect sympathomimetic

22
Q

Methamphetamine

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A

Indirect sympathomimetic

Higher ratio of central to peripheral action

23
Q

Methylphenidate

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A

Indirect sympathomimetic

Amphetamine variant, used in ADHD

24
Q

Cocaine

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A

Indirect sympathomimetic
Local anestetic
Blockade of uptake 1

25
Tyrosine
``` Indirect sympathomimetic Releases stored catecholamines Found in fermented foods (cheese) MAO inhibitors potentiate effects Can produce hypertensive crisis ```
26
Phentolamine
Prototypic alpha antagonist Nonselective between alpha 1 and 2 Competitive and reversible
27
Phenoxybenzamine
Alpha antagonist Irreversible (covalent binding) Somewhat selective to alpha 1 (less so than prazosin) Used in pheochromocytoma
28
Prazosin
Selective alpha 1 antagonist
29
Terazosin
Selective alpha 1 antagonist
30
Doxasosin
Alpha 1 antagonist with longer half life | Used for HTN and BPH
31
Tamsulosin
Competitive alpha 1 antagonist | Used in BPH
32
Alfuzosin
Competitive alpha 1 antagonist | Used in BPH
33
Yohimbine
Alpha2 selective antagonist | No clinical role
34
Reserpine
Indirect sympatholytic Irreversibly blocks vesicular monoamine transporter Storage of ALL catecholamines is inhibited Drug-induced parkinsonism
35
Propranolol
Prototypical beta-blocker | Nonselective
36
Metoprolol
Beta1-selective antagonist
37
Atenolol
Beta1-selective antagonist
38
Nadolol
Beta blocker | Long duration of action
39
Timolol
Beta blocker Long duration of action Used for glaucoma
40
Pindolol
Beta blocker partial agonist Significant intrinsic sympathomimetic effects
41
Acebutolol
Beta blocker partial agonist Significant intrinsic sympathomimetic effects
42
Carteolol
Beta blocker partial agonist Significant intrinsic sympathomimetic effects
43
Labetalol
Nonselective beta antagonist | Reversible alpha1 antagonist
44
Esmolol
Short acting beta1-selective antagonist | Ester linkage results in rapid hydrolysis
45
Butoxamine
Selective beta2 antagonist | No clinical application
46
Guanadrel
Adrenergic neuron blocking drug
47
Pendutolol
Nonselective beta antagonist
48
Levobunolol
Nonselective beta antagonist
49
Metipranolol
Nonselective beta antagonist
50
Betxolol
Beta-1 selective antagonist
51
Bisoprolol
Beta-1 selective antagonist
52
Nebivolol
Beta-1 selective antagonist

IC (5 decks)

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