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Cholingergic Pharm Flashcards

(48 cards)

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1
Q

Acetylcholine

A

Cholinoceptor agonist
Rapidly hydrolyzed
Both muscarinic and nicotinic action

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2
Q

Methacholine

A

Cholinoceptor agonist
Moderate resistance to hydrolysis
Only muscarinic activity

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3
Q

Carbachol chloride

A

Cholinoceptor agonist
Resistant to hydrolysis (long half life)
Both muscarinic and nicotinic action

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4
Q

Bethanechol Chloride

A

Cholinoceptor agonist
Resistant to hydrolysis (long half life)
Only muscarinic action

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5
Q

Edrophonium

A

Cholinesterase inhibitor
Short half life
Simple alcohol with quaternary ammonium group

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6
Q

Neostigmine

A

Cholinesterase inhibitor
Carbamate (quaternary structure)
Insoluble in lipids

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7
Q

Physostigmine

A

Cholinesterase Inhibitor
Carbamate (tertiary structure)
Distributes in CNS

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8
Q

Echothiophate

A

Cholinesterase inhibitor
Oranophosphate
NOT well absorbed topically

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9
Q

Nicotine

A

Direct nicotinic agonist

Toxicity (acute) causes CNS stimulation, respiratory paralysis, HTN, and cardiac arrhythmias

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10
Q

Varenicline

A

Direct nicotinic agonist

Used for smoking cessation

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11
Q

Cevimeline

A

Direct muscarinic agonist

Choline ester

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12
Q

Pilocarpine

A

Direct muscarinic agonist

Alkaloid

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13
Q

Pyridostigmine

A

Cholinesterase inhibitor

Carbamate

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14
Q

Rivastigmine

A

Cholinesterase inhibitor

Carbamate

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15
Q

Ambenonium

A

Cholinesterase inhibitor

Carbamate

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16
Q

Demecarium

A

Cholinesterase inhibitor

Carbamate

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17
Q

Carbaryl

A

Cholinesterase inhibitor

Carbamate

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18
Q

Soman

A

Cholinesterase inhibitor

Organophosphate

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19
Q

Sarin

A

Cholinesterase inhibitor

Organophosphate

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20
Q

Parathion

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A

Cholinesterase inhibitor

Organophosphate

21
Q

Malathion

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A

Cholinesterase inhibitor

Organophosphate

22
Q

Isoflurophate

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A

Cholinesterase inhibitor

Organophosphate

23
Q

Diisopropylfluorophosphate (DFP)

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A

Cholinesterase inhibitor

Organophosphate

24
Q

Donepezil

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A

Cholinesterase inhibitor

25
Tacrine
Cholinesterase inhibitor
26
Galantamine
Cholinesterase inhibitor
27
Atropine
Cholinoceptor blocker Reversible competitive Acts on M1, M2 and M3 subtypes
28
Scopolamine
Muscarinic antagonist | Tertiary amine
29
Homatropine
Muscarinic antagonist | Tertiary amine
30
Pirenzepine
Muscarinic antagonist | Tertiary amine
31
Tropicamide
Muscarinic antagonist | Tertiary amine
32
Tolterodine
Muscarinic antagonist | Tertiary amine
33
Dicyclomine
Muscarinic antagonist | Tertiary amine
34
Fesoteridine
Muscarinic antagonist | Tertiary amine
35
Mepenzolate
Muscarinic antagonist | Tertiary amine
36
Solifenacin
Muscarinic antagonist | Tertiary amine
37
Oxybutynin
Muscarinic antagonist | Tertiary amine
38
Darifenacin
Muscarinic antagonist | Tertiary amine
39
Trospium
Muscarinic antagonist | Tertiary amine
40
Atropine methyl nitrate
Muscarinic antagonist | Quaternary amine
41
Methscopolamine
Muscarinic antagonist | Quaternary amine
42
Ipratropium
Muscarinic antagonist | Quaternary amine
43
Propantheline
Muscarinic antagonist | Quaternary amine
44
Glycopyrrolate
Muscarinic antagonist | Quaternary amine
45
Hexamethonium
Ganglion blocking drug | Prototypic
46
Trimethaphan
Ganglion blocking drug | Lacks CNS effects
47
Mecamylamine
Ganglionic blocking drug
48
Pralidoxime
Cholinesterase regenerator

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