Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology Exam 3 > Adrenergics > Flashcards

Adrenergics Flashcards

(69 cards)

Start Studying
1
Q

SA node - B1 - __________

A

increased rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

AV node - B1 - __________

A

increased conduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ventricles - B1 - __________

A

increased contractility

Increased automaticity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Blood vessels in skin/mucosa - a1 - _________

A

constriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Blood vessels in skeletal muscle - B2 - ________

A

dilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Blood vessels in skeletal muscle - a1 - __________

A

constriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Blood vessels in abdominal viscera - a1 - _________

A

constriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Blood vessels in abdominal viscera - B2 - __________

A

dilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Blood vessels in lungs - a1 - __________

A

constriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

juxtaglomerular apparatus - B1 - __________

A

renin release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

GI - B2 - ___________

A

decreased motility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

GI - a1 - ___________

A

sphincter contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Bladder - B3 - ________

A

detrusor relaxation (prevent urination)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bladder - a1 - _________

A

sphincter contraction (urine retention)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Sex organs - a1 - ___________

A

ejaculation/orgasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

uterus - a1 - ____________

A

contraction in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

uterus - B2 - ___________

A

relaxation (pregnant or non pregnant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

prazosin

A

selective, reversible alpha 1 blocker

hypertension
PTSD
BPH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

phentolamine

A

nonselective alpha blockers, reversible

pheochromocytoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

phenoxybenzamine

A

alpha blocker, somewhat alpha1 selective, IRREVERSIBLE

BPH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

postural hypotension

reflex tachycardia (esp non-selective)

nasal conjestion

anorgasmia

ARE ADVERSE EFFECTS OF

A

ALPHA BLOCKERS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

EPI reversal

A

giving epi + alpha blocker reduces blood pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

lungs - B2 - ___________

A

bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

propranolol

A

nonselective beta blocker.
(but beta-2 blockade is overcome by beta-1 block)

antihypertensive
migraine ppx
performance anxiety
early in MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
``` heart block hypoglycemia in DM dyslipidemia bronchoconstriction CNS depression, lethargy SIDE EFFECTS OF ```
beta-blockers
26
timolol
non-selective beta blocker eye drops, for glaucoma
27
atenolol
selective beta-1 blocker
28
esmolol
selective beta-1 blocker 8 minute half life for emegency procedures
29
benefit of selective beta-1 blockers for treating hypertension
less risk of respiratory effects
30
enters via NET concentrates in vesicle slowly kicks out NE which is metabolized by MAO
guanethidine historically used for HTN
31
enters terminal and blocks vesicle, which prevents entry of NE into vesicle depletes NE over time
reserpine historically used for HTN
32
clonidine
direct alpha-2 agonists inhibit NE presynaptic release decrease sympathetic outflow
33
a-methyldopa
metabolized to a-methyl-NE | which acts as a2-agonist
34
pregnant patient with essential hypertension can take:
a-methyldopa
35
patient with opioid withdrawal symptoms might benefit from:
clonidine
36
how does a-2 agonist treat glaucoma?
decreases production of aqueous humor
37
treats ADHD
clonidine guanfacine (sympatholytic in brain)
38
dry mouth sedation hypertensive crisis after abrupt withdrawal
clonidine
39
dry mouth sedation autoimmune response (+ Coombs test)
a-methyldopa
40
dexemedetomide (Precedex)
a2 agonist
41
rhinitis
phenylephrine
42
bronchial asthma
terbutaline
43
cardiogenic shock
dopamine
44
heart failure
dobutamine
45
precursor to dopamine
tyrosine
46
dopamine --> ________ --> epinephrine
norepinephrine
47
most CIRCULATING epinephrine is metabolized by _____________.
monoamine oxidase (MOA) and catechol-o-methyl-transferase (COMPT)
48
NE levels WITHIN the terminal are regulated by ___________
monoamine oxidase
49
About 90% of released NE is recycled via _________
re-uptake by the presynaptic neuron at NET (NE transporter)
50
taken up by NET and vesicle in presynaptic neuron, | this rapidly kicks NE out of the vesicle which then diffuses into the terminal
amphetamine increases BP and HR
51
reversing action of the NET and increasing NE in the terminal is generally called:
FACILITATED EXCHANGE DIFFUSION
52
normally metabolized by MOA in the gut goes through NET and kicks NE out of presynaptic neuron --> hypertension
tyramine
53
blocks NET (reuptake of NE) leading to rapid increase of NE in the synapse
cocaine imipramine atomoxetine
54
phenylephrine
a1 agonist in nasal spray, constricts blood vessels in nose
55
chronic use of an adrenergic agonist causes ______ of receptors
desensitization and down regulation | except nicotine at nicotinic receptors
56
chronic use of adrenergic antagonist causes _______ of receptors
super sensitization and up-regulation
57
NE is released by______
postganglionic sympathetic neurons
58
NE likes to bind to ________ receptors
a1 and B1
59
Isoproterenol selectively binds to _______ receptors
Beta (1 and 2)
60
Epinephrine binds to _______ at low concentrations, but binds to ______ at high doses.
``` beta receptors (1 and 2) alpha ```
61
Dopamine binds to _______ most, but also binds ______ at low doses and ______ at high doses.
``` dopamine receptors beta receptors all receptors (promiscuous!) ```
62
Dobutamine preferentially binds to _______ receptors.
beta-1 | at high doses will bind to anything
63
Which drug stimulates contractility without affecting HR?
dobutamine
64
B1 receptors prefer __________ over _______ and ______.
isoproterenol | epi = NE
65
B2 receptors prefer ________ over ________ over ______.
isoproterenol > epi >> NE | NE likes the 1s
66
a1 receptors prefer _________ over _______ over _________.
epi > NE >> isoproterenol | iso likes beta
67
Drugs without hydroxyl groups get into the brain easily. These include:
phenylephrine ephedrine amphetamine
68
Which adrenergic agonist cannot be metabolized by MOA?
amphetamine
69
no reflex tachycardia
alpha-2 agonists

Pharmacology Exam 3 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions