Asthma/COPD Drugs

Question 1

systemic corticosteroid

Answer 1

methylprednisolone

Question 2

aerosol corticosteroid

Answer 2

fluticasone

Question 3

short acting beta agonists

Answer 3

albuterol

Question 4

long acting beta agonist

Answer 4

salmeterol

Question 5

short acting muscarinic antagonist

Answer 5

ipratropium bromide

Question 6

long acting muscarinic antagonist

Answer 6

tiotropium

Question 7

phosphodiesterase inhibitor

Answer 7

theophylline

Question 8

leukotriene pathway inhibitor

Answer 8

montelukast

Question 9

IgE inhibitor

Answer 9

omalizumab

Question 10

what is the effect of mast cell activation on the airway?

Answer 10

decreased diameter

increased mucus secretion

Question 11

drugs that affect airway responsiveness/reactivity for asthma

Answer 11

inhaled corticosteroids

Question 12

drugs that affect airway resistance for asthma

Answer 12

short-acting bronchodilators

IV or PO steroids

Question 13

adverse effect of inhaled corticosteroids

Answer 13

oral candidiasis

dysphonia

Question 14

systemic adverse effects of high dose ICS or PO steroids

Answer 14

bone resorption
skin thinning
growth retardation
(suppresses HPA axis)

Question 15

increase beta-2 receptors in airway

Answer 15

ICS

Question 16

useful in asthma but not really in COPD

Answer 16

ICS

Question 17

can be used as mono therapy in COPD but NOT in asthma

Answer 17

LABAs

Question 18

adverse effects of LABAs

Answer 18

muscle tremor
tachycardia
hypokalemia
tolerance

Question 19

which drug class is not anti-inflammatory?

Answer 19

muscarinic antagonists

Question 20

can be useful in COPD but not really in asthma

Answer 20

muscarinic antagonists

Question 21

which drug inhibits vaguely mediated airway tone to produce bronchodilator?

Answer 21

muscarinic antagonists

Question 22

which drug relaxes airway smooth muscle and inhibits release of mast cell mediators?

Answer 22

beta-2 agonists

Question 23

adverse effects of muscarinic antagonists

Answer 23

dry mouth
urinary retention
few side effects because poorly absorbed

Question 24

which drug inhibits cAMP phosphodiesterase in smooth muscle?

Answer 24

theophylline

Question 25

which drug increases diaphragm muscle contractility in COPD?

Answer 25

theophylline

Question 26

adverse effects of theophylline

Answer 26

narrow therapeutic window, monitor plasma levels cardio, CNS, and GI effects

Question 27

which drug is effective as an add on tx in aspirin-sensitive asthmatics?

Answer 27

leukotriene inhibitors | no role in COPD

Question 28

adverse effects of leukotriene inhibitors

Answer 28

``` hepatic dysfunction neuropsychiatric events (BBW) ```

Question 29

how to administer omalizumab

Answer 29

subcutaneous x 10 weeks | dose determined by serum IgE level

Question 30

downside of omalizumab

Answer 30

$$$$$$$$$$$$ | wide variation in response