Adult Still Disease

Question 1

What are the clinical features of Adult Still Disease?

Answer 1

1. Systemic form of juvenile chronic arthritis
2. High spiking fevers more prominent than arthritis
3. Nonpruritic rash (with fevers typically)
4. May have lymphadenopathy and pericardial effusions
5. Sore throat is common

Question 2

What temperature is associated with Adult Still Disease?

Answer 2

40 C or 104 F
*there will be daily spikes of that temp, with sweats and chills
*temperature will plunge w/out medication

Question 3

What demographic has the highest risk of Adult Still Disease?

Answer 3

Adults in 20s to 30s
*rare after age 60

Question 4

What color is the rash that is associated with Adult Still Disease?

Answer 4

Salmon colored/ pink migratory rash, transient
+/- Koebner phenomenon (the appearance of new skin lesions on previously unaffected skin secondary to trauma)

Question 5

What is present with Adult Still Disease?

Answer 5

1. Daily arthritis;
   *joint symptoms often develop months later if they do at all
2. Anemia, leukocytosis (high WBC) is usually present
   3.Elevated serum ferritin (iron levels can be higher)

Question 6

What is the the treatment for Adult Still Disease?

Answer 6

1. High dose ASA/ NSAIDs (half of the patients respond to this) the rest on prednisone
2. Use, TNF (tumor necrosis factor) inhibitors if refractory to ASA/ NSAIDs or anakinra
   *TNF will help stop inflammation