Adverse Effect Flashcards Preview

Heme Pharm > Adverse Effect > Flashcards

Flashcards in Adverse Effect Deck (60):
1

muscle cramps

Tyrosine kinase inhibitor - Imatinib

2

(1) Formation of inhibitors, anti-factor VIII/IX antibodies (IgG)(2) Viral infection(3) Thrombophlebitis at the infusion site(4) Bacterial contamination of the concentrate(5) Primary prophylaxis(a) Cost (very expensive)(b) Catheter-related infections (often a central venous line isnecessary)"

Factor VIII/IX replacement Plasma-derived products and Recombinant factor VIII/IX

3

Acute infusion reactions, associated particularly with the first infusion, including fever, chills, urticaria, headache, bronchospasm, angioedema and hypotension

Rituximab

4

a) Pulmonary emboli b) DVTc) MI

Prothrombin complex concentrate (PCC) and activated PCC(aPCC)

5

Inhibition of protein synthesis in normal tissues which can lead to hyperglycemia due to insulin deficiency, clotting abnormalities due to deficient clotting factors, and hypoalbuminemia

Asparaginase

6

stomatitis, conjunctivitis, dermatitis,

Cytarabine

7

Myelosuppression

flucytosine

8

Peripheral neuropathy

Fludarabine; Lamivudine (nucleoside analog of cytosine), Emtricitabine (fluorinated analog of lamivudine), Tenofovir (nucleotide analog of adenosine)

9

N/V; diarrhea, dizziness; rare: neutropenia, anemia, hemolysis, allergic reactions

Artemisinin

10

"Dose-related QT and PR intervals prolongation; Embryo-toxic, thus contraindicated in pregnancy"

Halofantrine

11

Rash which could progress to Stevens-Johnson syndrome

Nonnucleoside: Efavirenz and TMP/SMX and Pyrimethamine/sulfadiazine

12

Can cause anaphylaxis

iron dextran

13

a. Formation of inhibitors b. Viral infection associated with use of plasma-derived product sc. Thrombophlebitis at the infusion site

Plasma-derived vWF-containing products

14

neurotoxic, urotoxic, myelosuppression

cyclophosphamide

15

cardiotoxic

Doxorubicin, daunorubicin - anthracyclines

16

Mucositis

Doxorubicin, daunorubicin - anthracyclines; methotrexate

17

Cough, pyrexia, upper respiratory tract infection, rash, musculoskeletal symptoms, abdominal pain and postural dizziness, Hepatotoxicity

Penetration blocker: Maraviroc

18

ECG abnormalities

Mefloquine; Chloroquine; Quinine

19

Dry skin, cheilitis, reversible hepatic enzyme abnormalities

Tretinoin

20

– Hyperlipidemia– Leukopenia– Thrombocytopenia

sirolimus

21

Pruritus; Nausea, abdominal pain, blurring of vision; Hemolysis in persons deficient in G6PD; Hypotension; ECG changes: QRS widening; T wave abnormalities

Chloroquine

22

lipoatrophy

Lamivudine (nucleoside analog of cytosine), Emtricitabine (fluorinated analog of lamivudine), Tenofovir (nucleotide analog of adenosine)

23

Mitochondrial toxicity due to inhibition of mitochondrial DNA polymerase-γ

Lamivudine (nucleoside analog of cytosine), Emtricitabine (fluorinated analog of lamivudine), Tenofovir (nucleotide analog of adenosine)

24

pancreatitis

Lamivudine (nucleoside analog of cytosine), Emtricitabine (fluorinated analog of lamivudine), Tenofovir (nucleotide analog of adenosine)

25

Antigenicity as a foreign protein-Hypersensitivity reactions can occur and may be fatal

Asparaginase

26

seizures, dementia, and coma (cerebral toxicity)

Cytarabine

27

Peripheral neuropathy, pancreatitis, lipoatrophy, myopathy, anemia, increased transaminases Mitochondrial toxicity due to inhibition of mitochondrial DNA polymerase-γ

Lamivudine (nucleoside analog of cytosine), Emtricitabine (fluorinated analog of lamivudine), Tenofovir (nucleotide analog of adenosine)

28

can cause allergic reactions (pruritus, wheals,rash, anaphylaxis)

Deferoxamine

29

↑Risk of reactivating latent tuberculosis – screenpatients for TB; ↑Risk of demyelinating disease

TNF-α Inhibitors: Etanercept, Infliximab, Adalimumab

30

myelosuppression, N/V, anorexia

Mercaptopurine, Fludarabine

31

Lower risk of anaphylactic reactions

Sodium Ferric gluconate and iron sucrose

32

Hepatotoxicity

Penetration blocker: Maraviroc; cyclosporine; Amodiaquine; Protease inhibitors: Atazanavir, Darunavir, Ritonavir

33

Well-tolerated: diarrhea, nausea, dizziness, and headache

Integrase inhibitor: raltegravir

34

Hemolytic abnormalities; Hypoglycemia; ECG abnormalities; Flushing; Hypersensitivity reactions

Quinine and Quinidine

35

Diarrhea

leflunomide

36

Nephrotoxicity and pulmonary toxicity can occur after long-term use

methotrexate

37

reversible hepatic enzyme elevations, noncardiogenic pulmonary edema; GI disturbances; myelosuppression

Cytarabine

38

Metabolic changes including increased lipids, insulin insensitivity, and central fat accumulation

Protease inhibitors: Atazanavir, Darunavir, Ritonavir

39

Neutropenia, aplastic anemia and hepatotoxicity are common adverse effects

Amodiaquine

40

edema (ankles and periorbital tissues)

Tyrosine kinase inhibitor - Imatinib

41

Skin necrosis, fetal toxicity, and bleeding

warfarin

42

Cinchonism: Tinnitus; Headache; Visual disturbances; Nausea; Dizziness

Quinine and Quinidine

43

Almost all patients develop local injection site reactions,with mild or moderate pain, erythema, induration, nodules and cysts

enfuvirtide

44

hepato-, nephro-,& neuro—toxicity; hypertension, hyperlipidemia

cyclosporine

45

Prolonged high dose - Irreversible ototoxicity; retinopathy; myopathy; peripheral neuropathy

Chloroquine

46

bleeding and risk of hemorrhage; HIT

Heparin and LWMH

47

Tissue necrosis upon extravasation

Doxorubicin, daunorubicin - anthracyclines; dacarbazine

48

Facial flushing

DDAVP (desmopressin)

49

GI symptoms; photosensitivity

Doxycycline

50

↑Risk of cancer, especially bladder cancer

cyclophosphamide

51

ataxia and slurred speech (Cerebellar toxicity)

Cytarabine

52

Antidiuretic effects: water retention and dilutional hyponatremia

DDAVP (desmopressin)

53

(a) heartburn (b) constipation or diarrhea (c) nausea (more prevalent at higher doses) (d) upper abdominal pain (more prevalent at higher doses)

oral iron

54

N/V, Rash, Hepatitis, Endocrinologic abnormalities: women, menstrual irregularities; men, gynecomastia; due to inhibition of steroid biosynthesis

azoles, particularly ketoconazole

55

Abdominal pain, nausea, vomiting, diarrhea, rash

"Atovaquone-proguanilaka Malarone"

56

Hyperpigmentation, hyperkeratosis, erythema, and ulcerations over the elbows, knuckles, and other pressure areas

Bleomycin

57

Begins with cough and rales progressing to fibrosis;may be reversible but patients die of this complication.

Bleomycin

58

numbness and tingling of the extremities and loss of deep tendon reflexes, and motor weakness (Neurotoxicity)

vincristine

59

Stevens Johnson syndrome; kernicterus in infants; Acute hemolytic anemia in G6PD deficiency; Crystalluria

TMP/SMX and Pyrimethamine/sulfadiazine

60

Nephrotoxicity, normochromic and normocytic anemia

Polyenes: Amphotericin B