Contraindications

Question 1

Ingestion of large amounts of vitamin K-rich foods or supplements

Answer 1

decreases effectiveness of warfarin

Question 2

Hormone replacement therapy for hypothyroid patients

Answer 2

increases effectiveness of warfarin

Question 3

can increase the blood levels of the statin and increase the risk of rhabdomyolysis

Answer 3

Protease inhibitors: Atazanavir, Darunavir, Ritonavir

Question 4

pregnancy

Answer 4

warfarin; Nonnucleoside: Efavirenz

Question 5

Co-administration with tetracycline or rifampin

Answer 5

“Atovaquone-proguanil aka Malarone”

Question 6

Deferoxamine

Answer 6

Contraindicated in renal insufficiency and anuria

Question 7

Contraindicated in renal insufficiency and anuria

Answer 7

Deferoxamine

Question 8

High doses counteract the effects of antiepileptic drugs

Answer 8

Folic acid

Question 9

ferrous sulfate oral iron

Answer 9

antacids, proton-pump inhibitors, H2- receptor antagonists can interfere with absorption of many drugs; Avoid concurrent administration, separate doses by >2 hours.

Question 10

Concurrent use of drugs that reduce renal blood flow (e.g., non steroidal antiinflammatory agents), that are nephrotoxic (e.g., cisplatin), or that are weak organic acids (e.g., aspirin or piperacillin ) can delay drug excretion and lead to severe myelosuppression

Answer 10

methotrexate

Question 11

Fetal abnormalities (neural tube defects) can occur

Answer 11

Nonnucleoside: Efavirenz

Question 12

Anti-platelet drug (aspirin, clopidogrel) can increase the risk of bleeding

Answer 12

rivaroxaban

Question 13

Allopurinol inhibits xanthine oxidase, thereby increasing the bioavailability of what drug?

Answer 13

mercaptopurine

Question 14

Any disease that increases the risk of hemorrhage

Answer 14

warfarin

Question 15

Reduced absorption of drug caused by binding to cholestyramine in the gastrointestinal tract

Answer 15

decreases effectiveness of warfarin

Question 16

antacids, proton-pump inhibitors, H2- receptor antagonists

Answer 16

ferrous sulfate oral iron

Question 17

Elimination of intestinal flora by antimicrobial agents

Answer 17

increases effectiveness of warfarin

Question 18

can interfere with absorption of many drugs; Avoid concurrent administration, separate doses by >2 hours.

Answer 18

ferrous sulfate oral iron

Question 19

Other anticoagulants can increase the risk of bleeding

Answer 19

heparin and LMWH; rivaroxaban; Direct thrombin inhibitors: Lepirudin, Argatroban and dabigatran;

Question 20

Quinine and Quinidine

Answer 20

Mefloquine Al3+ containing antacids warfarin and digoxin