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Flashcards in Contraindications Deck (20):
1

Ingestion of large amounts of vitamin K-rich foods or supplements

decreases effectiveness of warfarin

2

Hormone replacement therapy for hypothyroid patients

increases effectiveness of warfarin

3

can increase the blood levels of the statin and increase the risk of rhabdomyolysis

Protease inhibitors: Atazanavir, Darunavir, Ritonavir

4

pregnancy

warfarin; Nonnucleoside: Efavirenz

5

Co-administration with tetracycline or rifampin

"Atovaquone-proguanil aka Malarone"

6

Deferoxamine

Contraindicated in renal insufficiency and anuria

7

Contraindicated in renal insufficiency and anuria

Deferoxamine

8

High doses counteract the effects of antiepileptic drugs

Folic acid

9

ferrous sulfate oral iron

antacids, proton-pump inhibitors, H2- receptor antagonists can interfere with absorption of many drugs; Avoid concurrent administration, separate doses by >2 hours.

10

Concurrent use of drugs that reduce renal blood flow (e.g., non steroidal antiinflammatory agents), that are nephrotoxic (e.g., cisplatin), or that are weak organic acids (e.g., aspirin or piperacillin ) can delay drug excretion and lead to severe myelosuppression

methotrexate

11

Fetal abnormalities (neural tube defects) can occur

Nonnucleoside: Efavirenz

12

Anti-platelet drug (aspirin, clopidogrel) can increase the risk of bleeding

rivaroxaban

13

Allopurinol inhibits xanthine oxidase, thereby increasing the bioavailability of what drug?

mercaptopurine

14

Any disease that increases the risk of hemorrhage

warfarin

15

Reduced absorption of drug caused by binding to cholestyramine in the gastrointestinal tract

decreases effectiveness of warfarin

16

antacids, proton-pump inhibitors, H2- receptor antagonists

ferrous sulfate oral iron

17

Elimination of intestinal flora by antimicrobial agents

increases effectiveness of warfarin

18

can interfere with absorption of many drugs; Avoid concurrent administration, separate doses by >2 hours.

ferrous sulfate oral iron

19

Other anticoagulants can increase the risk of bleeding

heparin and LMWH; rivaroxaban; Direct thrombin inhibitors: Lepirudin, Argatroban and dabigatran;

20

Quinine and Quinidine

Mefloquine Al3+ containing antacids warfarin and digoxin