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Flashcards in AEDs Deck (64):
1

This drug is an anti-arrhythmic

Phenytoin

2

This drug can cause fetal hydantoin syndrome

Phenytoin

3

Dose related ADRs: nystagmus, ataxia, drowsiness, cognitive impairment

Phenytoin

4

Non-dose related ADRs: GINGIVAL HYPERPLASIA, hirsutism, acne, rash, hepatotoxicity

Phenytoin

5

Dose related ADRs: vertigo, ataxia, diplopia, drowsiness, nausea

Carbamazepine

6

CNS side effects: HA, paresthesias, confusion, psychosis

Carbamazepine

7

Non-specific side effects: SIADH, leukopenia, thrombocytopenia, Stevens-Johnson Syndrome

Carbamazepine

8

This drug is good for neonatal and febrile seizures

Phenobarbital

9

This is a prodrug structurally related to phenobarbital

Primidone

10

This drug is metabolized through autoinduction

Carbamazepine

11

This drug is metabolized hepatically and does not induce P450

Valproic Acid/ Valproate

12

This drug blocks Na channels AND enhancement of GABAergic transmission

Valproic Acid/ Valproate

13

Dose related ADRs: N,V, abdominal pain, diarrhea, sedation, tremor, unsteadiness

Valproic Acid

14

Non-dose related ADRs: acute hepatic failure, acute pancreatitis

Valproic Acid

15

This drug inhibits calcium channels

Ethosuximide

16

This is the DOC for absence seizures

Ethosuximide

17

Dose related side effects: GI, lethargy, HA, dizziness, anxiety

Ethosuximide

18

This drug is metabolized by but is not an inducer of P450

Ethosuximide

19

ADRs: dizziness, fatigue, GI, hyponatremia, and rash. Has a 30% cross reactivity for rash with another AED

Oxcarbazepine

20

This drug is an analogue of GABA, has a nick PK profile, and can treat peripheral neuropathy as well as partial and GTC seizures

Gabapentin

21

ADRs: somnolence, dizziness, ataxia, nystagmus

Gabapentin

22

This drug is a competitive inhibitor of GABA transporter

Tiagabine

23

Dose related ADRs: dizziness, fatigue, nervousness, difficulty concentrating

Tiagabine

24

This drug blocks both Na and Ca channels

Lamotrigine

25

This drug is metabolized via Phase II

Lamotrigine

26

ADRs: rash, confusion, depression, N, V, diplopia, severe idiosyncratic (skin, blood) reactions

Lamotrigine

27

Slow taper is ESSENTIAL for this drug

Lamotrigine

28

This drug blocks Na channels and opens Cl channels

Topiramate

29

Dose related ADRs: drowsiness, parasthesias, psychomotor slowing, weight loss, renal calculi

Topiramate

30

It is essential to maintain adequate fluids with this drug in order to lessen the chance of developing renal calculi

Topiramate

31

This drug blocks sodium channels, competes for NMDA receptors, prevents AMPA receptor stimulation, and blocks Na channels

Felbamate

32

This drug is used for patients with Lennox-Gastaut syndrome

Felbamate

33

Non- dose related ADRs include aplastic anemia and liver failure

Felbamate

34

Dose related ADRs include anorexia, N/V, insomnia, and HA

Felbamate

35

This drug has a favorable PK profile and is available in parenteral form. You would need to adjust the dose for renal insufficiency

Levetiracetam

36

Side effects include sedation and behavioral abnormalities

Levetiracetam

37

This drug is a sulfonamide derivative

Zonisamide

38

This drug is renally AND hepatically eliminated

Zonisamide

39

Dose related ADRs: sedation, dizziness, cognitive impairment, nausea

Zonisamide

40

Non-dose related ADRs: rash, oligohydrosis, kidney stones

Zonisamide

41

This drug is never used alone for seizures, but rather used as an adjunctive treatment for partial onset seizures

Pregabalin

42

This drug is often used for peripheral neuropathy, postherpetic neuralgia, and fibromyalgia

Pregabalin

43

Side effects include dizziness, somnolence, dry mouth, peripheral edema, blurred vision, and weight gain

Pregabalin

44

This class of drug is first choice for SE

Benzodiazepines: Lorazepam or Diazepam

45

Besides benzos, what else can be used to treat SE?

Hydantoins (Fosphenytoin or phenytoin)
Barbituates (Phenobarbital)

46

This class of drugs act as positive allosteric modulators by enhancing channel gating in the presence of GABA

benzos

47

ADRs include: infusion rate related arrhythmias and hypotension, respiratory depression, and impairment of consciousness

benzos

48

This is the DOC in SE patients with IV access

Lorazepam

49

True or false: Diazepam is preferred over lorazepam for the treatment of SE secondary to duration of action

FALSE. Lorazepam DOA is 12-24 hours, whereas Diazepam DOA is 15 min to 2 hours

50

This class of drug is second line therapy for SE. It has less CNS and respiratory depression than benzos and barbs

Hydantoins

51

This class of drugs can cause arrhythmias, nystagmus, dizziness, and ataxia

Hydantoins

52

H2O soluble prodrug of phenytoin

Fosphenytoin

53

This drug is highly lipophilic and quickly redistributes out of the brain to other fat stores in the body

Diazepam

54

True or false: fosphenytoin contains propylene glycol

FALSE. Phenytoin does

55

This drug is 3rd line agent for SE if sz persists despite 2-3 doses of benzos and a loading dose of hydantoin

Phenobarbital

56

This drug is 2nd line agent for SE if sz persists after 2-3 doses of benzos and hydantoins are contraindicated

Phenobarbital

57

ADRs include: more CNS and respiratory depression than hydantoins

Phenobarbital

58

True or False: Phenobarbital contains proplyene glycol

TRUE

59

These are 3 AEDs that cause prolonged inactivation of the voltage-sensitive sodium channel

Phenytoin
Carbamazepine
Lamotrigine

60

These drugs (3) DIRECTLY enhance GABA-mediated inhibition

BZDP
Barbs
Topiramate (we think)

61

These drugs (3) INDIRECTLY enhance GABA- mediated inhibition

Gabapentin
Tiagabine
Vigabatrin

62

These 2 drugs reduce glutaminergic excitation

Phenobarbital
Topiramate

63

This drug has an extraordinarily long half life and time to steady state

Phenobarbital

64

This drug is a benzo used for refractive SE

Midazolam (Versed)