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Flashcards in Asthma Deck (51):
1

Which class of drugs is best for the immediate-phase response of an asthma attack

bronchodilators

2

Which class of drugs is best for the late phase response of an asthma attack

anti-inflammatory drugs

3

Drugs that can trigger an asthma attack

cardioselective and nonselective beta blockers, calcium antagonists, dipyridamole, NSAIDs

4

Long term control asthma medications

corticosteroids
LABA
leuktriene modifiers
methylxanthines
cromolyn
anti IgE

5

Quick relief for asthma

SABA
anticholinergics
systemic corticosteroids

6

This class of drug depresses the inflammatory response and edema in the respiratory tract and diminishes bronchial hyper-responsiveness

ICS

7

This class is the most effective long term control therapy for persistent asthma and is the only therapy shown to reduce the risk of death from asthma

ICS

8

CAUTION in growing children

ICS

9

Local ADRs include thrush , dysphonia, reflex cough and bronchospasm

ICS

10

Systemic effects could potentially include HPA axis suppression, impaired growth in children and dermal thinning (dose dependent)

ICS

11

ICS messes with BMD, cataracts, and glaucoma in kids. T or F

FALSE! ICS at low to moderate dose is safe!

12

This class is not a substitute for anti-inflam therapy and should not be used as monotherapy. Not for acute exacerbations

LABA

13

This class causes loss of protection with methacholine, histamine, and exercise

LABA

14

This class should not be used with CYP3A4 inhibitors- ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, telithromycin

LABA

15

This class of drug competitively antagonizes leukotriene receptors D4 and E4 in the bronchiolar muscle, antagonizing endogenous molecules that cause bronchodilation

leukotriene receptor antagonists

16

this class is an alternative treatment of mild persistent asthma

LRA

17

CONTRAINDICATIONS in pregnancy, caution in elderly

LRA

18

These two LRAs are associated with liver toxicity, contraindicated in pts with liver disease

Zileuton and Zafirlukast

19

this class can cause GI disturbances, HA, respiratory infections

LRAs (zafirlukast and montelukast for resp infections)

20

this LRA interacts with warfarin, increasing prothrombin time

zafirlukast

21

this LRA doubles theophylline concentration, increases prothrombin time (warfarin), and doubles propranolol levels

zileuton

22

this class increases cAMP levels in the bronchial smooth muscle cells inhibiting phosphodiesterase- causes smooth muscle relaxation and bronchodilation

Methylxanthines

23

This class is indicated in refractory patients. It can be used as monotherapy or in combo with an ICS

methylxanthines

24

Dont use this class if you are a child under 4, have cardiac disease, HTN, or hepatic impairment

methylxanthines

25

This class has a narrow theraputic window, tons of drug-drug interactions, and safer alternatives

methylxanthines

26

This class interacts with cimetidine, macrolides, quinolones and is a CYP1A2 and 3A4 substrate

methylxanthines

27

this class can cause nausea, irritability, insomnia, HA, vomiting, tachyarrhythmias, ventricular arrhythmias, seizures

methylxanthines

28

this class stabilizes mast cells preventing the release of inflammatory mediators

mast cell stabilizers

29

indications for this class include patients less than 20 with severe allergic disease and moderate asthma OR pregnancy

mast cell stabilizers

30

ADRs for this class include cough, transient bronchospasm, throat irritation

mast cell stabilizer

31

this class is reserved for moderate to severe persistent asthma in patients 12 or older who are not controlled on other therapies (not first line therapy)

omalizumab

32

this drug works bc it is a recombinant monoclonal antibody that binds IgE on mast cells and basophils, so it limits the release of mediators of allergic response

omalizumab

33

this drug has a favorable safety profile, but a BBW for anaphylaxis

omalizumab

34

this class decreases inflammation by suppression of migration of leukocytes and reversal of increased capillary permeability

systemic corticosteroids

35

this class is used for control of chronic symptoms in people with severe asthma

systemic corticosteroids

36

this class stimulates b2 adrenoceptors, leading to a rise in intracellular cAMP- subsequent smooth muscle relaxation and bronchodilation

SABA

37

this class is indicated for relief of bronchospasm during acute exacerbations, and pretreatment for exercise induced bronchoconstriction

SABA

38

ADRs include fine tremor, tachycardia, hypokalemia

SABA

39

this class is indicated for relief of acute bronchospasm, can provide additive effects to B2 agonists in an acute setting

anticholinergics

40

treatment of choice for bronchospasm due to B blockers

anticholinergics

41

Contraindicated in glaucoma and pregnancy

anticholinergics

42

this class is important in the treatment of severe acute asthma exacerbations

systemic corticosteroids

43

mild intermittent asthma treatment

SABA

44

mild persistent asthma treatment

low dose ICS, SABA

45

moderate persistent asthma treatment

low dose ICS, LABA, SABA

46

severe persistent asthma treatment

medium or high dose ICS, LABA, oral glucocorticosteroid (SABA)

47

COPD pts get adequate relief from bronchodilators and anti-inflammatory agents. T or F

F

48

primary therapy for COPD

oxygen

49

Should I administer O2 to a pt with severe COPD who is retaining CO2

NOPE- depresses resp drive

50

DOC in COPD patients

anticholinergic agents (beta 2 agonists should be combined)

51

antibiotics can be used in a COPD patient when?

increased dyspnea, increased sputum volume, increased sputum purulence