Cystic Fibrosis Flashcards Preview

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Flashcards in Cystic Fibrosis Deck (26):
1

therapy for pancreatic enzyme replacement

creon, zenpep, pancreaze (contain lipase, protease, amylase)

2

this class can cause nausea, abd cramps, constipation, diarrhea, greasy stools, flatulence. Fibrosing colonopathy at high doses

pancreatic enzyme replacement

3

clinical issues with this class include inadequate enteric coating leading to denaturing and poor outcomes when switched to generic

pancreatic enzyme replacement

4

this disease increases in CF patients as they age

Diabetes

5

pharmacotherapy for pt with diabetes

insulin

6

therapy for distal intestinal obstruction syndrome

electrolyte lavage solutions until the patient passes stool

7

treatment for GERD in a CF pt

antacids
H2 blockers
PPI

8

pt w CF has high GGT levels. How do you treat

Ursodeoxycholate

9

this drug decreases liver inflammation and bile duct proliferation

Ursodeoxycholate

10

As maintenance therapy, this improves ventilation and reduces the accumulation of secretions

ACT (airway clearance techniques)

11

are oral corticosteroids a good option for AI therapy in CF

NO, undesirable SEs

12

this anti-inflam therapy decreases rate of decline of FEV1

NSAIDs (ibu)

13

this AI therapy slows the FEV1 decline in CF pts with pseudomonas and can improve FEV1

Azithromycin

14

this is a chronic therapy for CF. It decreases viscosity of sputum. An aerosolized recombinant dornase alfa

Pulmozyme

15

this drug shows improvement in FEV1 and decreased pulm exacerbation. AEs include hoarseness, voice alteration, and pharyngitis

Pulmozyme

16

this mucolytic is not commonly used bc it is irritating and causes bronchoconstriction

Mucomyst (n-acetylcystine)

17

this therapy allows pt to draw water into airways, increasing the ability to cough out mucous. May be associated w chronic cause and bronchospasm

nebulized hypertonic

18

these chronic therapies may be useful in CF pts with asthma

inhaled B2 agonists
ICS

19

major pathogen 1st year of life

staph aureus

20

major pathogen by age 3

h influenzae

21

major pathogen by age 5

pseudomonas (Colonized)

22

This chronic antibiotic is nebulized tobramycin and covers for pseudomonas

TOBI

23

this chronic ab is nebulized aztreonam and covers pseudomonas

Cayston

24

this class is used chronically and prolongs time between acute CF exacerbations

chronic abx

25

Ab therapy for an acute CF exacerbation

cover staph aureus and h influ (pseudo based on sensitivities)
generally aminoglycosides plus antipseudomonal penicillin. Dose HIGH. CF have high Vd and Cl

26

Chronic therapy dietary CF

high calorie (120-150% RDA)
Vit A,D,E,K
may need more salt
multivitamins