Alcohol Related Disease Flashcards Preview

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Flashcards in Alcohol Related Disease Deck (19):
1

What does alcohol cause in the liver causing direct toxicity?

Hypoglycaemia
Acidosis
Ketosis
Steatosis
Steatohepatitis

2

What can alcohol cause in the alimentary system?

Hepatic encephalopathy
Spontaneous bacterial peritonitis
Alcoholic hepatitis

3

What is hepatic encephalopathy?

Permanent brain dysfunction as a result of liver failure

4

What are the causes of hepatic encephalopathy?

Infection
Drugs
Constipation
GI bleed
Electrolyte disturbance

5

What are the signs of advanced liver disease?

Spider naevi
Palmar erythema
Gynaecomastia
Loss of axillary and pubic hair
Ascites
Encephalopathy
Jaundice
Muscle wasting

6

What lab investigations would be done to diagnose liver disease?

AAT and ALT
Gamma Glutamyl Transferase (GGT)
MAcrocytosis
Thrombocytopenia

7

What is the treatment of hepatic encephalopathy?

Bowel clear out - lactulose or enema
Antibiotics for any underlying infection
Supportive care - ITU, airway support, nasogastric tube

8

What are the signs and symptoms of spontaneous bacterial peritonitis?

Abdominal pain
Fever/rigors
Renal impairment
Signs of sepsis - tachycardia, fever
Ascites

9

What investigations would be done if suspecting spontaneous bacterial peritonitis?

Ascitic tap
Fluid protein and glucose levels
Fluid culture
White cell content

10

What is the treatment for spontaneous bacterial peritonitis?

IV antibiotics
Ascetic fluid drainage
IV albumin infusion

11

What is the typical presentation of alcoholic hepatitis?

Jaundice
Encephalopathy
Infection
Decompensated liver function - low albumin, raised prothrombin time

12

What investigations would be done if suspecting alcoholic hepatitis?

Bilirubin levels
GGT
Alkaline phosphatase
Alcohol history

13

What is the treatment of alcoholic hepatitis?

Palliative
Treat infection and encephalopathy
Treat alcohol withdrawal
Protect against GI bleeding
ITU care
Treat any renal damage
Steroids if severe grading on Glasgow Alcoholic Hepatitis score
Nutritional supplements

14

What is fatty liver disease related to?

Obesity
Diabetes
Hypercholesterolaemia
Alcohol

15

What is steatohepatitis?

Fat and inflammation in the liver

16

The histology of steatohepatitis will be similar to the histology of what other condition?

Alcohol induced liver damage

17

What proportion of patients with fatty liver disease will progress to cirrhosis?

1/4

18

What investigations would be done if suspecting fatty liver disease?

Ultrasound
Liver biopsy
ALT

19

What is the treatment for fatty liver disease?

Treatment based on causative factors
Weight loss, alcohol abstinence etc.