Allylamine and Echinocandin drugs Flashcards Preview

42 Antifungal drugs > Allylamine and Echinocandin drugs > Flashcards

Flashcards in Allylamine and Echinocandin drugs Deck (11):
1

Allylamine drugs (2 drugs)

Naftifine
Terbinafine

2

Allylamine drugs - MOA

Inhibit squalene epoxidase, inhibiting formation of lanosterol and ergosterol

3

Allylamine drugs - indications

Superficial dermatophyte infections

4

Terbinafine - indications

Onychomycosis (nails)

5

Naftifine and terbinafine - adverse effects

Well tolerated, rarely serious adverse effects.

6

Echinocandin drugs (3 drugs)

Caspofungin
Micafungin
Anidulafungin

7

Echinocandins - MOA

Inhibits β-(1,3)-D-D-glucan synthase enzyme complex. This inhibits cell wall synthesis and causes disruption of cell wall and lysis of the cell.

8

Caspofungin - indications

Esophageal, oropharyngeal and invasive candidiasis.
Invasive aspergillosis

9

Caspofungin - adverse effects

Headache, fever
Phlebitis at injection site
Abnormal liver function tests

10

Caspofungin - adm

IV

11

Micafungin and Anidulafungin - Indications

Candidial infections
Invasive aspergillosis