General + Polyene drugs Flashcards Preview

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Flashcards in General + Polyene drugs Deck (12):
1

Polyene antibiotics (3 drugs)

Amphotericin B
Natamycin
Nystatin

2

Polyene drugs - MOA

Binds ergosterol in fungal cell membrane and increases the membrane permeability (leakage of cell components).
Also bind to mammalian cholesterol - renal adverse effects

3

Polyene antibiotic indicated for systemic and subcutaneous mycoses

Amphotericin B

4

Which polyene drugs are only adm topically? (2 drugs)

Natamycin
Nystatin

5

Polyene antibiotic to treat fungal meningitis (1 drug)

Amphotericin B

6

Amphotericin B - adverse effects

Renal toxicity (80% of pt)
Hypokalemia, hypomagnesemia.
Azothemia
Acute liver failure, cardiac arrhythmias.
Anemia, leukopenia, thrombocytopenia

7

How can side effects of Amphotericin B be reduced?

Reduced nephrotoxicity with parenteral lipid formulations.
Reduced fever, vomiting ect by pretreatment with corticosteroids, antipyretic drugs, antihistamines.

8

Nystatin - indications

Candidiasis (mucocutaneous, intestinal and vaginal)

9

Natamycin - indications

Fungal blepharitis, conjunctivitis and keratitis (by aspergillus, candida, fusarium, penicillium species)

10

Antifungal drugs (4 groups, + 4 other drugs)

Polyene antibiotics
Azole derivatives
Allylamine drugs
Echinocandin drugs
Others (ciclopirox, flucytosine, griseofluvin, tolnafate)

11

Amphotericin B - indications

Severe systemic mycoses

12

Which drugs are alternatives to amphotericin B?

Azole derivatives