Other antifungal drugs Flashcards Preview

42 Antifungal drugs > Other antifungal drugs > Flashcards

Flashcards in Other antifungal drugs Deck (11):
1

Other antifungals (that are not polyenes, azoles, allylamines, or ehcinocandins) (4 drugs)

Flucytosine
Griseofluvin
Ciclopirox
Tolnaftate

2

Flucytosine - MOA

Its metabolite (5-FU) is incorporated into fungal RNA. Interferes with protein synthesis

3

Flucytosine - indications

Severe fungal infections.
Pneumonia, meningitis, endocarditis and septicemia (Candida and cryptococcus)

4

Flucytosine is used with which drug and why?

Amphotericin B. Synergistic effect.
When flucytosine is used alone, drug resistance develops rapidly

5

Flucytosine - adverse effects

Hematologic toxicity
Cardiopulmonary arrest

6

Griseofluvin - MOA

It is deposited in keratin precursor cells of skin, hair and nails. Disrupts microtubule function and inhibits mitosis of dermatophytes.

7

Standard treatment for tinea capitis (1 drug)

Griseofluvin

8

Griseofluvin - adverse effects

Dizziness
Insomnia
GI bleeding
Hepatitis
Leukopenia

9

Griseofluvin - interactions

Decrease plasma concentrations of:
Contraceptives
Barbiturates
Warfarin

10

Ciclopriox - indications

Skin infections and onychomycosis by dermatophytes, candida, M. furfur

11

Tolnaftate - indications

Tinea versicolor
Mild dermatophyte skin infections